Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0369 | 0.0569 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0347 | 0.0501 | 0.5 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.0347 | 0.0501 | 0.0501 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0369 | 0.0569 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.3355 | 1 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0525 | 0.1064 | 0.0592 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.3355 | 1 | 1 |
Echinococcus multilocularis | G protein coupled receptor kinase 1 | 0.3007 | 0.8904 | 0.8846 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0369 | 0.0569 | 0.5 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.3355 | 1 | 1 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0347 | 0.0501 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.3355 | 1 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0525 | 0.1064 | 0.0592 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 0.0501 | 0.0501 |
Loa Loa (eye worm) | RGS-3 protein | 0.0347 | 0.0501 | 0.0501 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0347 | 0.0501 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0355 | 0.0528 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 0.0501 | 0.0501 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 0.0501 | 0.0501 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0347 | 0.0501 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0347 | 0.0501 | 0.5 |
Echinococcus granulosus | G protein coupled receptor kinase 1 | 0.3007 | 0.8904 | 0.8846 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 0.0501 | 0.0501 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0355 | 0.0528 | 0.0528 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0347 | 0.0501 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0347 | 0.0501 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0347 | 0.0501 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0369 | 0.0569 | 0.0569 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 0.0501 | 0.0501 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.0355 | 0.0528 | 0.39 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 0.0501 | 0.0501 |
Entamoeba histolytica | hypothetical protein | 0.0347 | 0.0501 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0369 | 0.0569 | 0.5 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0347 | 0.0501 | 0.0501 |
Entamoeba histolytica | hypothetical protein | 0.0347 | 0.0501 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 3 ug ml-1 | In vitro cytotoxicity of the compound was evaluated againstrenal CAKI-1 cells; 3 x 10E1 | ChEMBL. | 10780904 |
IC50 (functional) | > 3 ug ml-1 | In vitro cytotoxicity of the compound was evaluated againstcolon DLD-1 cells; 3 x 10E1 | ChEMBL. | 10780904 |
IC50 (functional) | > 3 ug ml-1 | In vitro cytotoxicity of the compound was evaluated againstlung NCI-H23 cells; 3 x 10E1 | ChEMBL. | 10780904 |
IC50 (functional) | > 3 ug ml-1 | In vitro cytotoxicity of the compound was evaluated againstmelanoma SK-MEL-28 cells; 3 x 10E1 | ChEMBL. | 10780904 |
IC50 (functional) | > 3 ug ml-1 | In vitro cytotoxicity of the compound was evaluated againstCNS SNB-7 cells; 3 x 10E1 | ChEMBL. | 10780904 |
IC50 (functional) | > 3 ug ml-1 | In vitro cytotoxicity of the compound was evaluated againstrenal CAKI-1 cells; 3 x 10E1 | ChEMBL. | 10780904 |
IC50 (functional) | > 3 ug ml-1 | In vitro cytotoxicity of the compound was evaluated againstcolon DLD-1 cells; 3 x 10E1 | ChEMBL. | 10780904 |
IC50 (functional) | > 3 ug ml-1 | In vitro cytotoxicity of the compound was evaluated againstlung NCI-H23 cells; 3 x 10E1 | ChEMBL. | 10780904 |
IC50 (functional) | > 3 ug ml-1 | In vitro cytotoxicity of the compound was evaluated againstmelanoma SK-MEL-28 cells; 3 x 10E1 | ChEMBL. | 10780904 |
IC50 (functional) | > 3 ug ml-1 | In vitro cytotoxicity of the compound was evaluated againstCNS SNB-7 cells; 3 x 10E1 | ChEMBL. | 10780904 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 10780904 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.