Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | microtubule associated protein 2 | 0.0713 | 0.1906 | 0.2478 |
Loa Loa (eye worm) | ryanodine receptor | 0.0788 | 0.2338 | 0.4255 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0713 | 0.1906 | 0.2478 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.076 | 0.2179 | 0.5 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.076 | 0.2179 | 0.5 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0645 | 0.1508 | 0.0785 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0713 | 0.1906 | 0.1217 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.1332 | 0.5494 | 0.7158 |
Loa Loa (eye worm) | ryanodine receptor | 0.0498 | 0.0655 | 0.1193 |
Loa Loa (eye worm) | hypothetical protein | 0.1332 | 0.5494 | 1 |
Echinococcus granulosus | ryanodine receptor 44f | 0.1332 | 0.5494 | 0.7158 |
Loa Loa (eye worm) | hypothetical protein | 0.0401 | 0.0096 | 0.0175 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.1707 | 0.7672 | 1 |
Echinococcus granulosus | ryanodine receptor 44f | 0.1707 | 0.7672 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0517 | 0.0767 | 0.5 |
Schistosoma mansoni | ryanodine receptor related | 0.2109 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LD app (ADMET) | = 0.41 mM kg-1 | Lethal dose of the compound that killed mice in 48 hr | ChEMBL. | 7031248 |
LD app (ADMET) | = 0.41 mM kg-1 | Lethal dose of the compound that killed mice in 48 hr | ChEMBL. | 7031248 |
MED (functional) | = 0.43 (mg of base) 20g-1 | Minimum effective dose of the compound which on 5th day reduced the mean infection level to one-fiftieth of the control | ChEMBL. | 7031248 |
MED (functional) | = 0.43 (mg of base) 20g-1 | Minimum effective dose of the compound which on 5th day reduced the mean infection level to one-fiftieth of the control | ChEMBL. | 7031248 |
Ratio (functional) | = 2.8 | Ratio of activity of quinine versus compound against P. berghei in mice | ChEMBL. | 7031248 |
Time (functional) | = 3 hr | Time taken for In vitro anti-filarial activity to immobilize breinlia booliati (adult worms) | ChEMBL. | 7031248 |
Time (functional) | = 6 hr | Time taken for In vitro anti-filarial activity to immobilize breinlia booliati (Microfilaria) | ChEMBL. | 7031248 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.