Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0247 | 0 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.0247 | 0 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0258 | 0.1137 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0344 | 1 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0247 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0344 | 1 | 1 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0247 | 0 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0247 | 0 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0247 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0 % | Inhibition ofandrogen receptor in reporter gene (chloramphenicol acetyltransferase) assay in HeLa cells | ChEMBL. | No reference |
Activity (functional) | = 0 % | Inhibition ofandrogen receptor in reporter gene (chloramphenicol acetyltransferase) assay in HeLa cells | ChEMBL. | No reference |
Amount of TNF-alpha (functional) | = 2 % | Inhibition of 50 nM okadaic acid induced tumor necrosis factor-alpha production in human leukemia cell line (HL-60) by 0.3 uM. | ChEMBL. | 9288167 |
Amount of TNF-alpha (functional) | = 2 % | Inhibition of 50 nM okadaic acid induced tumor necrosis factor-alpha production in human leukemia cell line (HL-60) by 0.3 uM. | ChEMBL. | 9288167 |
Amount of TNF-alpha (functional) | = 100 % | Amount of tumor necrosis factor-alpha produced by human leukemia cell line (HL-60) stimulated with 10 nM12-O-tetradecanoylphorbol 13-acetate (TPA) at 0.3 microM, measured by ELISA | ChEMBL. | 9288167 |
Amount of TNF-alpha (functional) | = 100 % | Amount of tumor necrosis factor-alpha produced by human leukemia cell line (HL-60) stimulated with 10 nM12-O-tetradecanoylphorbol 13-acetate (TPA) at 0.3 microM, measured by ELISA | ChEMBL. | 9288167 |
IC50 (functional) | = 2.8 ug ml-1 | The cytotoxicity of the compounds assessed using human embryonic lung fibroblast WI-38 cells at (8 micro M) | ChEMBL. | 9288167 |
IC50 (functional) | = 2.8 ug ml-1 | The cytotoxicity of the compounds assessed using human embryonic lung fibroblast WI-38 cells at (8 micro M) | ChEMBL. | 9288167 |
No. of cells (functional) | = 14 | Growth inhibition of androgen-dependent clonal cell line SC-3, derived from Shionogi carcinoma 115 | ChEMBL. | No reference |
Production (functional) | = 2 % | Compound was evaluated for the amount of TNF-alpha produced by HL-60 cells in the presence of Okadaic acid (OA) at concentration 0.3 microM | ChEMBL. | No reference |
Production (functional) | = 2 % | Compound was evaluated for the amount of TNF-alpha produced by HL-60 cells in the presence of Okadaic acid (OA) at concentration 0.3 microM | ChEMBL. | No reference |
Production (functional) | = 100 % | Compound was evaluated for the amount of TNF-alpha produced by HL-60 cells in the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA) at concentration 0.3 microM | ChEMBL. | No reference |
Production (functional) | = 100 % | Compound was evaluated for the amount of TNF-alpha produced by HL-60 cells in the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA) at concentration 0.3 microM | ChEMBL. | No reference |
Production (functional) | = 101 % | Production of TNF-alpha by HL-60 cells in the presence of 300 nM okadaic acid | ChEMBL. | No reference |
Production (functional) | = 101 % | Production of TNF-alpha by HL-60 cells in the presence of 300 nM okadaic acid | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 9288167 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.