Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium avium | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.061 | 0.8703 | 0.8703 |
Loa Loa (eye worm) | hypothetical protein | 0.061 | 0.8703 | 0.8703 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.4965 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0676 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.4965 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0676 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0676 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.4965 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0676 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.061 | 0.8703 | 0.8703 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0421 | 0.4965 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0676 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0676 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0676 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0676 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.4965 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.4965 | 0.5 |
Loa Loa (eye worm) | TKL/MLK/LZK protein kinase | 0.061 | 0.8703 | 0.8703 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0676 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.061 | 0.8703 | 0.8703 |
Schistosoma mansoni | serine/threonine protein kinase | 0.062 | 0.8898 | 0.8898 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 25 nM | Inhibitory concentration against dihydrofolate reductase of Mycobacterium avium | ChEMBL. | 14998335 |
IC50 (binding) | = 25 nM | Inhibitory concentration against dihydrofolate reductase of Mycobacterium avium | ChEMBL. | 14998335 |
IC50 (binding) | = 1500 nM | Inhibitory concentration against dihydrofolate reductase of Toxoplasma gondii | ChEMBL. | 14998335 |
IC50 (binding) | = 1500 nM | Inhibitory concentration against dihydrofolate reductase of Toxoplasma gondii | ChEMBL. | 14998335 |
IC50 (binding) | = 7100 nM | Inhibitory concentration against dihdrofolate reductace enzyme of Pneumocystis carinii | ChEMBL. | 14998335 |
IC50 (binding) | = 7100 nM | Inhibitory concentration against dihdrofolate reductace enzyme of Pneumocystis carinii | ChEMBL. | 14998335 |
IC50 (binding) | = 13000 nM | Inhibitory concentration against dihydrofolate reductase of rat liver | ChEMBL. | 14998335 |
IC50 (binding) | = 13000 nM | Inhibitory concentration against dihydrofolate reductase of rat liver | ChEMBL. | 14998335 |
SI (binding) | = 1.8 | Ratio of DHFR inhibition of rat liver to that of Pneumocystis carinii | ChEMBL. | 14998335 |
SI (binding) | = 8.7 | Ratio of DHFR inhibition of rat liver to that of Toxoplasma gondii | ChEMBL. | 14998335 |
SI (binding) | = 520 | Ratio of DHFR inhibition of rat liver to that of Mycobacterium avium | ChEMBL. | 14998335 |
SI (binding) | = 1.8 | Ratio of DHFR inhibition of rat liver to that of Pneumocystis carinii | ChEMBL. | 14998335 |
SI (binding) | = 8.7 | Ratio of DHFR inhibition of rat liver to that of Toxoplasma gondii | ChEMBL. | 14998335 |
SI (binding) | = 520 | Ratio of DHFR inhibition of rat liver to that of Mycobacterium avium | ChEMBL. | 14998335 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.