Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0165 | 1 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0068 | 0.3032 | 0.2234 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1027 | 0.1027 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.3712 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.3712 | 1 |
Echinococcus multilocularis | protein patched | 0.0068 | 0.3032 | 0.2234 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.2261 | 0.2261 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0068 | 0.3032 | 0.2234 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0068 | 0.3032 | 0.2234 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.3032 | 0.3032 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 1 | 1 |
Echinococcus multilocularis | caspase 2 | 0.0057 | 0.2261 | 0.1375 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.004 | 0.1027 | 0.1027 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0068 | 0.3032 | 0.2234 |
Echinococcus multilocularis | protein dispatched 1 | 0.0068 | 0.3032 | 0.2234 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0068 | 0.3032 | 0.3032 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0068 | 0.3032 | 0.2234 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0078 | 0.3712 | 0.5 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0057 | 0.2261 | 0.1375 |
Brugia malayi | CHE-14 protein | 0.0068 | 0.3032 | 0.3032 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0068 | 0.3032 | 0.2234 |
Schistosoma mansoni | patched 1 | 0.0068 | 0.3032 | 0.2234 |
Echinococcus granulosus | caspase 2 | 0.0057 | 0.2261 | 0.1375 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0165 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0 | 0.5 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0057 | 0.2261 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.3712 | 1 |
Brugia malayi | Cell death protein 3 precursor | 0.0057 | 0.2261 | 0.2261 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0 | Inhibition of cholesterol synthesis in L6 myocytes | ChEMBL. | 17764936 |
IC50 (binding) | = 5.4 nM | Inhibition of HMG-CoA reductase in rat liver microsomes | ChEMBL. | 17764936 |
IC50 (binding) | = 5.4 nM | Inhibition of HMG-CoA reductase in rat liver microsomes | ChEMBL. | 17764936 |
IC50 (functional) | = 9.9 nM | Inhibition of cholesterol synthesis in rat hepatocytes | ChEMBL. | 17764936 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.