Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | amiloride sensitive amine oxidase | 0.0177 | 0.5363 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.027 | 0.9164 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0189 | 0.5857 | 0.5 |
Echinococcus granulosus | amiloride sensitive amine oxidase | 0.0177 | 0.5363 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.029 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.5363 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0189 | 0.5857 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0189 | 0.5857 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0189 | 0.5857 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0189 | 0.5857 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0189 | 0.5857 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0189 | 0.5857 | 0.5 |
Schistosoma mansoni | copper/topaquinone oxidase | 0.0177 | 0.5363 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.09 uM | Inhibition of human CDK2/cyclin A | ChEMBL. | 17904841 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.