Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Mycobacterium avium | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6822 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.1512 | 0.1204 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.035 | 0.5 |
Giardia lamblia | DNA repair protein RAD52 | 0.0338 | 0.6739 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.1512 | 0.1512 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0468 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.035 | 0.035 |
Brugia malayi | Probable ClpP-like protease | 0.0083 | 0.035 | 0.035 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6822 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0102 | 0.0807 | 0.0807 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.1512 | 0.1204 |
Entamoeba histolytica | DNA repair and recombination protein RAD52, putative | 0.0338 | 0.6739 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0807 | 0.0807 |
Brugia malayi | Serotonin receptor | 0.0453 | 0.9634 | 0.9634 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6822 | 1 |
Brugia malayi | thymidylate synthase | 0.013 | 0.1512 | 0.1512 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.1512 | 0.1512 |
Brugia malayi | Dihydrofolate reductase | 0.0468 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0468 | 1 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.035 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0.1512 | 0.1204 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.1512 | 0.1204 |
Onchocerca volvulus | 0.013 | 0.1512 | 0.5 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0102 | 0.0807 | 0.0807 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0083 | 0.035 | 0.035 |
Echinococcus granulosus | dihydrofolate reductase | 0.0468 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0468 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0468 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0468 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0468 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6822 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0102 | 0.0807 | 0.0807 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0341 | 0.6822 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6822 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0468 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 310 nM | Inhibitory concentration against dihydrofolate reductase of Mycobacterium avium | ChEMBL. | 14998335 |
IC50 (binding) | = 310 nM | Inhibitory concentration against dihydrofolate reductase of Mycobacterium avium | ChEMBL. | 14998335 |
IC50 (binding) | = 710 nM | Inhibitory concentration against dihydrofolate reductase of Toxoplasma gondii | ChEMBL. | 14998335 |
IC50 (binding) | = 710 nM | Inhibitory concentration against dihydrofolate reductase of Toxoplasma gondii | ChEMBL. | 14998335 |
IC50 (binding) | = 7800 nM | Inhibitory concentration against dihdrofolate reductace enzyme of Pneumocystis carinii | ChEMBL. | 14998335 |
IC50 (binding) | = 7800 nM | Inhibitory concentration against dihdrofolate reductace enzyme of Pneumocystis carinii | ChEMBL. | 14998335 |
IC50 (binding) | = 25000 nM | Inhibitory concentration against dihydrofolate reductase of rat liver | ChEMBL. | 14998335 |
IC50 (binding) | = 25000 nM | Inhibitory concentration against dihydrofolate reductase of rat liver | ChEMBL. | 14998335 |
SI (binding) | = 3.2 | Ratio of DHFR inhibition of rat liver to that of Pneumocystis carinii | ChEMBL. | 14998335 |
SI (binding) | = 35 | Ratio of DHFR inhibition of rat liver to that of Toxoplasma gondii | ChEMBL. | 14998335 |
SI (binding) | = 81 | Ratio of DHFR inhibition of rat liver to that of Mycobacterium avium | ChEMBL. | 14998335 |
SI (binding) | = 3.2 | Ratio of DHFR inhibition of rat liver to that of Pneumocystis carinii | ChEMBL. | 14998335 |
SI (binding) | = 35 | Ratio of DHFR inhibition of rat liver to that of Toxoplasma gondii | ChEMBL. | 14998335 |
SI (binding) | = 81 | Ratio of DHFR inhibition of rat liver to that of Mycobacterium avium | ChEMBL. | 14998335 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.