Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carbonic anhydrase | 0.098 | 0.2916 | 0.3479 |
Echinococcus multilocularis | carbonic anhydrase | 0.098 | 0.2916 | 0.3479 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1957 | 0.6432 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.25 | 0.8384 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.098 | 0.2916 | 0.3479 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.25 | 0.8384 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.098 | 0.2916 | 0.3479 |
Schistosoma mansoni | hypothetical protein | 0.098 | 0.2916 | 0.3479 |
Echinococcus granulosus | carbonic anhydrase II | 0.25 | 0.8384 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.098 | 0.2916 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.2293 | 0.7641 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.25 | 0.8384 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.25 | 0.8384 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.25 | 0.8384 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.25 | 0.8384 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2949 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.098 | 0.2916 | 0.3479 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.2293 | 0.7641 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.25 | 0.8384 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.2293 | 0.7641 | 0.9114 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.25 | 0.8384 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.1302 | 0.4073 | 0.321 |
Echinococcus granulosus | carbonic anhydrase | 0.098 | 0.2916 | 0.3479 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.25 | 0.8384 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.25 | 0.8384 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.098 | 0.2916 | 0.3479 |
Echinococcus multilocularis | carbonic anhydrase | 0.098 | 0.2916 | 0.3479 |
Echinococcus multilocularis | carbonic anhydrase | 0.098 | 0.2916 | 0.3479 |
Echinococcus multilocularis | carbonic anhydrase II | 0.25 | 0.8384 | 1 |
Toxoplasma gondii | hypothetical protein | 0.098 | 0.2916 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.098 | 0.2916 | 0.3479 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2949 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antimicrobial activity against Saccharomyces cerevisiae at 1 mg/mL by agar-well diffusion assay | ChEMBL. | 7760078 | |
Activity (functional) | Antimicrobial activity against Candida albicans | ChEMBL. | 10346966 | |
Activity (functional) | Antimicrobial activity against Escherichia coli at 1 mg/mL by agar-well diffusion assay | ChEMBL. | 7760078 | |
Activity (ADMET) | 0 | Cytotoxicity against human HL60 cells after 48 hrs by MTT assay | ChEMBL. | 17291040 |
Activity (ADMET) | 0 | Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay | ChEMBL. | 17291040 |
IC50 (ADMET) | 0 | Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay | ChEMBL. | 17291040 |
IC50 (ADMET) | > 10 uM | Antiproliferative activity against HMEC1 cells by SRB assay | ChEMBL. | 18078313 |
IC50 (functional) | > 10 uM | Antiproliferative activity against human HL60 cells by SRB assay | ChEMBL. | 18078313 |
IC50 (functional) | > 10 uM | Antiproliferative activity against human A459 cells by SRB assay | ChEMBL. | 18078313 |
IC50 (functional) | > 10 uM | Antiproliferative activity against human HL60 cells by SRB assay | ChEMBL. | 18078313 |
IZ (functional) | = 1 mm | Antimicrobial activity against Cryptococcus neoformans at 1 mg/mL by agar-well diffusion assay | ChEMBL. | 7760078 |
IZ (functional) | = 1 mm | Antimicrobial activity against Candida albicans at 1 mg/mL by agar-well diffusion assay | ChEMBL. | 7760078 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 18078313 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.