Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0166 | 0.5 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0166 | 0.5 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0166 | 0.5 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0166 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 26.7 uM | Inhibition of human thrombin | ChEMBL. | 17883259 |
IC50 (binding) | = 26.7 uM | Inhibition of human thrombin | ChEMBL. | 17883259 |
IC50 (binding) | > 40.2 uM | Inhibition of human recombinant DPP4 | ChEMBL. | 17883259 |
IC50 (binding) | > 40.2 uM | Inhibition of human recombinant DPP4 | ChEMBL. | 17883259 |
MIC (functional) | = 64.3 uM | Antibacterial activity against Helicobacter pylori ATCC43504 by agar dilution method | ChEMBL. | 17883259 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.