Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.0667 | 0.0667 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.0486 | 0.0486 |
Echinococcus multilocularis | integrin alpha 3 | 0.0258 | 0.2552 | 1 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0192 | 0.0667 | 0.2616 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0192 | 0.0667 | 0.2616 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.0192 | 0.0667 | 0.5 |
Echinococcus granulosus | integrin alpha 3 | 0.0258 | 0.2552 | 1 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0254 | 0.2454 | 0.5118 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.273 | 0.273 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0336 | 0.4795 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0192 | 0.0667 | 0.2616 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0192 | 0.0667 | 0.5 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0192 | 0.0667 | 0.2616 |
Schistosoma mansoni | integrin alpha | 0.0336 | 0.4795 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.2454 | 0.2454 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 4 mM | Inhibition of Plasmodium falciparum ODCase | ChEMBL. | 18181562 |
Ki (binding) | = 5.7 mM | Inhibition of Methanobacterium thermoautotrophicum ODCase | ChEMBL. | 18181562 |
Ki (binding) | = 7.2 mM | Inhibition of human ODCase | ChEMBL. | 18181562 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.