Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.2925 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0074 | 1 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0074 | 1 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0074 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.2925 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.2925 | 0.2925 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.2925 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0018 | 0.03 | 0.1026 |
Onchocerca volvulus | 0.0033 | 0.2925 | 0.5 | |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.2925 | 0.2925 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0074 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.2925 | 0.2925 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2925 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.2925 | 1 |
Onchocerca volvulus | 0.0033 | 0.2925 | 0.5 | |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0074 | 1 | 0.5 |
Echinococcus multilocularis | lamin | 0.0033 | 0.2925 | 0.2925 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.2925 | 0.2925 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0074 | 1 | 0.5 |
Echinococcus multilocularis | musashi | 0.0033 | 0.2925 | 0.2925 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0074 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.2821 | 0.9646 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0074 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0074 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 1.9 | Activation of SMN2 promoter in mouse NSC34 cells assessed as induction of beta-lactamase activity relative to nonactivated cells | ChEMBL. | 18205293 |
EC50 (functional) | = 0.25 uM | Activation of SMN2 promoter in mouse NSC34 cells assessed as induction of beta-lactamase activity | ChEMBL. | 18205293 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.