Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Peroxisome proliferator-activated receptor alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | IPR008946,Nuclear receptor, ligand-binding,domain-containing | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma japonicum | ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | ecdysone induced protein 78C | Peroxisome proliferator-activated receptor alpha | 468 aa | 409 aa | 30.8 % |
Brugia malayi | ecdysteroid receptor | Peroxisome proliferator-activated receptor alpha | 468 aa | 375 aa | 25.1 % |
Brugia malayi | Steroid receptor seven-up type 2 | Peroxisome proliferator-activated receptor alpha | 468 aa | 381 aa | 24.1 % |
Schistosoma mansoni | retinoic acid receptor RXR | Peroxisome proliferator-activated receptor alpha | 468 aa | 398 aa | 28.4 % |
Echinococcus granulosus | ecdysone induced protein 78C | Peroxisome proliferator-activated receptor alpha | 468 aa | 409 aa | 30.8 % |
Loa Loa (eye worm) | hypothetical protein | Peroxisome proliferator-activated receptor alpha | 468 aa | 376 aa | 27.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 0.0059 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0022 | 0.0059 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0022 | 0.0059 | 0.0143 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0022 | 0.0059 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0059 | 0.5 |
Echinococcus granulosus | geminin | 0.0184 | 0.4092 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0022 | 0.0059 | 0.0084 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.4092 | 0.4092 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0059 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0022 | 0.0059 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0059 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0059 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.0059 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.6964 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 0.0059 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.6964 | 1 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.4092 | 0.4092 |
Brugia malayi | NNMT/PNMT/TEMT family protein | 0.03 | 0.6964 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0059 | 0.5 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.03 | 0.6964 | 1 |
Echinococcus multilocularis | geminin | 0.0184 | 0.4092 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.0059 | 0.0059 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0022 | 0.0059 | 0.0143 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0022 | 0.0059 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0059 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0.0059 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.0059 | 0.0059 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0022 | 0.0059 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0.0059 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 7.54 uM | Agonist activity at rat PPARalpha in rat H4IIE cells assesed as gene induction | ChEMBL. | 18029176 |
EC50 (functional) | = 7.54 uM | Agonist activity at rat PPARalpha in rat H4IIE cells assesed as gene induction | ChEMBL. | 18029176 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.