Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0008 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0416 | 0.2503 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0012 | 0.1662 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0012 | 0.1662 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0008 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0.1662 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0012 | 0.1662 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.1662 | 0.1662 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.1662 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.1662 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.1662 | 0.1662 |
Trypanosoma brucei | cytochrome P450, putative | 0.0012 | 0.1662 | 0.5 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0.1662 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC10 (functional) | = 13.6 uM | Cytotoxicity against human HeLa cells | ChEMBL. | 17966985 |
CC10 (functional) | = 13.6 uM | Cytotoxicity against human HeLa cells | ChEMBL. | 17966985 |
CC50 (functional) | = 29 uM | Cytotoxicity against human HeLa cells | ChEMBL. | 17966985 |
CC50 (functional) | = 29 uM | Cytotoxicity against human HeLa cells | ChEMBL. | 17966985 |
GI50 (functional) | = 33.7 uM | Antiproliferative activity against human K562 cells | ChEMBL. | 17966985 |
GI50 (functional) | = 33.7 uM | Antiproliferative activity against human K562 cells | ChEMBL. | 17966985 |
GI50 (ADMET) | = 57.2 uM | Antiproliferative activity against mouse L929 cells | ChEMBL. | 17966985 |
GI50 (ADMET) | = 57.2 uM | Antiproliferative activity against mouse L929 cells | ChEMBL. | 17966985 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.