Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0133 | 0.0306 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0076 | 0.0133 | 0.044 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0076 | 0.0133 | 0.00000021581 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.292 | 0.6712 |
Brugia malayi | Uncoordinated protein 44 | 0.0076 | 0.0133 | 0.044 |
Brugia malayi | Protein kinase domain containing protein | 0.0076 | 0.0133 | 0.044 |
Echinococcus multilocularis | adam 17 protease | 0.0223 | 0.1712 | 0.16 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.014 | 0.0819 | 0.0696 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0345 | 0.3022 | 0.2928 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0076 | 0.0133 | 0.000000048003 |
Brugia malayi | hypothetical protein | 0.0271 | 0.2226 | 0.7367 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0077 | 0.0138 | 0.0025 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0345 | 0.3022 | 0.2928 |
Brugia malayi | Death domain containing protein | 0.0076 | 0.0133 | 0.044 |
Schistosoma mansoni | jun-related protein | 0.028 | 0.2328 | 1 |
Echinococcus granulosus | Ankyrin | 0.0077 | 0.0138 | 0.0005 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0105 | 0.0448 | 0.1433 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0994 | 1 | 1 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.014 | 0.0819 | 0.0696 |
Echinococcus multilocularis | jun protein | 0.0345 | 0.3022 | 0.2928 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0105 | 0.0448 | 0.0319 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0096 | 0.0345 | 0.0214 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0105 | 0.0448 | 0.0319 |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.4351 | 1 |
Schistosoma mansoni | hypothetical protein | 0.028 | 0.2328 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0076 | 0.0133 | 0.0306 |
Brugia malayi | bZIP transcription factor family protein | 0.0345 | 0.3022 | 1 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0223 | 0.1712 | 0.7195 |
Echinococcus granulosus | jun protein | 0.0345 | 0.3022 | 0.2928 |
Onchocerca volvulus | 0.0271 | 0.2226 | 1 | |
Echinococcus multilocularis | Ankyrin | 0.0077 | 0.0138 | 0.0005 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0076 | 0.0133 | 0.000000048003 |
Echinococcus granulosus | adam 17 protease | 0.0245 | 0.1951 | 0.1842 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0096 | 0.0345 | 0.0214 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0105 | 0.0448 | 0.1481 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0138 | 0.0318 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.