Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0312 | 0.0661 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0193 | 0.4282 | 0.6004 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0261 | 0.6226 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0043 | 0.0058 | 1 |
Trypanosoma brucei | CAAX amino terminal protease, putative | 0.0208 | 0.4725 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.0312 | 0.0438 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.0208 | 0.4725 | 1 |
Mycobacterium tuberculosis | Probable integral membrane protein | 0.0043 | 0.0058 | 0.0093 |
Echinococcus multilocularis | geminin | 0.0193 | 0.4282 | 0.9062 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0208 | 0.4725 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0193 | 0.4282 | 1 |
Mycobacterium tuberculosis | Probable conserved integral membrane protein | 0.0043 | 0.0058 | 0.0093 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.4282 | 0.9062 |
Treponema pallidum | hypothetical protein | 0.0043 | 0.0058 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0058 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0293 | 0.7132 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0193 | 0.4282 | 0.6004 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0193 | 0.4282 | 0.6004 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.0208 | 0.4725 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0043 | 0.0058 | 0.0093 |
Plasmodium falciparum | protease, putative | 0.0043 | 0.0058 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0193 | 0.4282 | 0.6004 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0208 | 0.4725 | 0.4694 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0293 | 0.7132 | 1 |
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.0208 | 0.4725 | 1 |
Mycobacterium tuberculosis | Probable conserved integral membrane protein | 0.0043 | 0.0058 | 0.0093 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0208 | 0.4725 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0193 | 0.4282 | 0.6004 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0312 | 0.0661 |
Toxoplasma gondii | CAAX amino terminal protease family protein | 0.0043 | 0.0058 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0058 | 1 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.0208 | 0.4725 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0041 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0293 | 0.7132 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0293 | 0.7132 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0293 | 0.7132 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0293 | 0.7132 | 1 |
Chlamydia trachomatis | hypothetical protein | 0.0043 | 0.0058 | 0.5 |
Giardia lamblia | DNA repair protein RAD52 | 0.0395 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.2019 | 0.1972 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0193 | 0.4282 | 0.6004 |
Toxoplasma gondii | hypothetical protein | 0.0043 | 0.0058 | 1 |
Plasmodium vivax | protease, putative | 0.0043 | 0.0058 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0312 | 0.0661 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0193 | 0.4282 | 0.6004 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0312 | 0.0661 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.0208 | 0.4725 | 1 |
Brugia malayi | CAAX amino terminal protease family protein | 0.0208 | 0.4725 | 0.6626 |
Mycobacterium ulcerans | integral membrane protein | 0.0043 | 0.0058 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0203 | 0.4575 | 0.6415 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.4282 | 0.9062 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0312 | 0.0661 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0293 | 0.7132 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0312 | 0.0661 |
Echinococcus granulosus | geminin | 0.0193 | 0.4282 | 0.9062 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0293 | 0.7132 | 1 |
Entamoeba histolytica | Rad52/22 family double-strand break repair protein, putative | 0.0112 | 0.2019 | 0.1972 |
Mycobacterium leprae | Probable lipase LipE | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.4725 | 0.6626 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0312 | 0.0661 |
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.0208 | 0.4725 | 0.6626 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.0312 | 0.0438 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0203 | 0.4575 | 0.6415 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 12 % | Parasiticidal activity against Ctenocephalides felis after 8 hrs by cat flea assay | ChEMBL. | 18006308 |
LD99 (functional) | = 2 uM | Parasiticidal activity against Haemonchus contortus by larval assay | ChEMBL. | 18006308 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.