Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APH1B gamma secretase subunit | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma japonicum | ko:K06172 anterior pharynx defective 1, putative | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus granulosus | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Brugia malayi | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0 | 0.5 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0115 | 0.3443 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0 | 0.5 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0296 | 1 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0115 | 0.3443 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0252 | 0.84 | 0.84 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0296 | 1 | 1 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0296 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0296 | 1 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0252 | 0.84 | 0.84 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0 | 0.5 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0115 | 0.3443 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 11 nM | Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels | ChEMBL. | 18023581 |
IC50 (binding) | = 11 nM | Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels | ChEMBL. | 18023581 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.