Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | integrin alpha-4 | Get druggable targets OG5_133980 | All targets in OG5_133980 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | integrin alpha 3 | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | 1032 aa | 873 aa | 22.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Dihydrofolate reductase | 0.034 | 0.5498 | 0.4981 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.1411 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0127 | 0.1349 | 0.0711 |
Brugia malayi | follicle stimulating hormone receptor | 0.0229 | 0.3339 | 0.2573 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0127 | 0.1349 | 0.0711 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.013 | 0.1411 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.034 | 0.5498 | 0.5 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.011 | 0.1031 | 0.1031 |
Schistosoma mansoni | dihydrofolate reductase | 0.034 | 0.5498 | 0.6806 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.2203 | 0.2727 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0229 | 0.3339 | 0.3339 |
Schistosoma mansoni | thyroid hormone receptor | 0.0157 | 0.1932 | 0.2391 |
Schistosoma mansoni | integrin alpha-ps | 0.011 | 0.1031 | 0.1276 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.013 | 0.1411 | 0.5 |
Echinococcus multilocularis | geminin | 0.0171 | 0.2203 | 0.2623 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0157 | 0.1932 | 0.2017 |
Echinococcus granulosus | geminin | 0.0171 | 0.2203 | 0.2623 |
Chlamydia trachomatis | dihydrofolate reductase | 0.034 | 0.5498 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.034 | 0.5498 | 0.4981 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.013 | 0.1411 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.034 | 0.5498 | 0.5498 |
Schistosoma mansoni | integrin alpha | 0.011 | 0.1031 | 0.1276 |
Echinococcus granulosus | dihydrofolate reductase | 0.034 | 0.5498 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.013 | 0.1411 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.1411 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0127 | 0.1349 | 0.1669 |
Schistosoma mansoni | thyroid hormone receptor | 0.0157 | 0.1932 | 0.2391 |
Echinococcus multilocularis | dihydrofolate reductase | 0.034 | 0.5498 | 1 |
Schistosoma mansoni | integrin alpha-4 | 0.0472 | 0.8079 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.034 | 0.5498 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.2203 | 0.2727 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.034 | 0.5498 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.