Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | ADAM metallopeptidase domain 10 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | disintegrin family protein | Get druggable targets OG5_131201 | All targets in OG5_131201 |
Schistosoma mansoni | dihydroceramide desaturase | Get druggable targets OG5_131201 | All targets in OG5_131201 |
Brugia malayi | Disintegrin family protein | Get druggable targets OG5_131201 | All targets in OG5_131201 |
Schistosoma japonicum | ko:K04712 fatty acid desaturase, putative | Get druggable targets OG5_131201 | All targets in OG5_131201 |
Echinococcus granulosus | disintegrin and metalloproteinase | Get druggable targets OG5_131201 | All targets in OG5_131201 |
Echinococcus multilocularis | disintegrin and metalloproteinase | Get druggable targets OG5_131201 | All targets in OG5_131201 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Matrixin family protein | 0.0051 | 0.0761 | 0.046 |
Onchocerca volvulus | Matrilysin homolog | 0.0047 | 0 | 0.5 |
Schistosoma mansoni | dihydroceramide desaturase | 0.0102 | 1 | 1 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0068 | 0.3833 | 0.3632 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.005 | 0.0598 | 0.0291 |
Echinococcus multilocularis | disintegrin and metalloproteinase | 0.0102 | 1 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0077 | 0.5397 | 0.5247 |
Loa Loa (eye worm) | disintegrin family protein | 0.0074 | 0.4978 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.3833 | 0.77 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0068 | 0.3833 | 0.3632 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0077 | 0.5397 | 0.5247 |
Echinococcus granulosus | disintegrin and metalloproteinase | 0.0102 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0051 | 0.0761 | 0.1529 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0047 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 261 nM | Inhibition of ADAM10 (unknown origin) | ChEMBL. | 18068976 |
IC50 (binding) | = 261 nM | Inhibition of ADAM10 (unknown origin) | ChEMBL. | 18068976 |
IC50 (binding) | = 358 nM | Inhibition of HER2 sheddase in human BT474 cells | ChEMBL. | 18068976 |
IC50 (binding) | = 358 nM | Inhibition of HER2 sheddase in human BT474 cells | ChEMBL. | 18068976 |
IC50 (binding) | = 549 nM | Inhibition of MMP2 (unknown origin) | ChEMBL. | 18068976 |
IC50 (binding) | = 549 nM | Inhibition of MMP2 (unknown origin) | ChEMBL. | 18068976 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.