Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Homo sapiens | ADAM metallopeptidase domain 10 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | disintegrin and metalloproteinase | Get druggable targets OG5_131201 | All targets in OG5_131201 |
Schistosoma japonicum | ko:K04712 fatty acid desaturase, putative | Get druggable targets OG5_131201 | All targets in OG5_131201 |
Echinococcus granulosus | disintegrin and metalloproteinase | Get druggable targets OG5_131201 | All targets in OG5_131201 |
Schistosoma mansoni | dihydroceramide desaturase | Get druggable targets OG5_131201 | All targets in OG5_131201 |
Loa Loa (eye worm) | disintegrin family protein | Get druggable targets OG5_131201 | All targets in OG5_131201 |
Brugia malayi | Disintegrin family protein | Get druggable targets OG5_131201 | All targets in OG5_131201 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | disintegrin and metalloproteinase | 0.0102 | 0.4327 | 0.4327 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0058 | 0.0748 | 0.14 |
Onchocerca volvulus | Matrilysin homolog | 0.0105 | 0.4574 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0058 | 0.0748 | 0.5 |
Loa Loa (eye worm) | disintegrin family protein | 0.0074 | 0.2083 | 0.2908 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0068 | 0.1572 | 0.1572 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0068 | 0.1572 | 0.1572 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0172 | 1 | 1 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.005 | 0.0126 | 0.0291 |
Loa Loa (eye worm) | matrixin family protein | 0.0115 | 0.5339 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0105 | 0.4574 | 0.8334 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0105 | 0.4574 | 1 |
Echinococcus granulosus | disintegrin and metalloproteinase | 0.0102 | 0.4327 | 0.4327 |
Brugia malayi | Matrixin family protein | 0.0115 | 0.5339 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0058 | 0.0748 | 0.5 |
Brugia malayi | Disintegrin family protein | 0.0102 | 0.4327 | 0.8104 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1572 | 0.1795 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.1513 | 0.3496 |
Schistosoma mansoni | dihydroceramide desaturase | 0.0102 | 0.4327 | 1 |
Brugia malayi | Hemopexin family protein | 0.0067 | 0.1513 | 0.2833 |
Mycobacterium ulcerans | hydrolase | 0.0058 | 0.0748 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.8 nM | Inhibition of ADAM10 (unknown origin) | ChEMBL. | 18068976 |
IC50 (binding) | = 7.8 nM | Inhibition of ADAM10 (unknown origin) | ChEMBL. | 18068976 |
IC50 (binding) | = 13 nM | Inhibition of HER2 sheddase in human BT474 cells | ChEMBL. | 18068976 |
IC50 (binding) | = 13 nM | Inhibition of HER2 sheddase in human BT474 cells | ChEMBL. | 18068976 |
IC50 (binding) | > 2000 nM | Inhibition of MMP2 (unknown origin) | ChEMBL. | 18068976 |
IC50 (binding) | > 2000 nM | Inhibition of MMP2 (unknown origin) | ChEMBL. | 18068976 |
IC50 (binding) | > 5000 nM | Inhibition of MMP1 (unknown origin) | ChEMBL. | 18068976 |
IC50 (binding) | > 5000 nM | Inhibition of MMP1 (unknown origin) | ChEMBL. | 18068976 |
Stabilty (ADMET) | = 50 % | Metabolic stability in human liver microsomes | ChEMBL. | 18068976 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.