Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0296 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0296 | 1 | 0.5 |
Plasmodium vivax | lysophospholipase, putative | 0.0296 | 1 | 1 |
Plasmodium vivax | unspecified product | 0.0296 | 1 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0296 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0289 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0289 | 0 | 0.5 |
Leishmania major | monoglyceride lipase, putative | 0.0289 | 0 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0289 | 0 | 0.5 |
Mycobacterium ulcerans | lysophospholipase | 0.0289 | 0 | 0.5 |
Plasmodium falciparum | esterase, putative | 0.0296 | 1 | 1 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0289 | 0 | 0.5 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0289 | 0 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0289 | 0 | 0.5 |
Plasmodium falciparum | esterase, putative | 0.0296 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kinact (binding) | = 400 nM | Binding affinity to inactivated rat Nav1.2 sodium channel expressed in HEK293 cells | ChEMBL. | 17489575 |
Kinact (binding) | = 400 nM | Binding affinity to inactivated rat Nav1.2 sodium channel expressed in HEK293 cells | ChEMBL. | 17489575 |
KR (binding) | = 30 uM | Binding affinity to inactivated rat brain Nav1.2 sodium channel expressed in HEK293 cells | ChEMBL. | 17489575 |
KR (binding) | = 30 uM | Binding affinity to inactivated rat brain Nav1.2 sodium channel expressed in HEK293 cells | ChEMBL. | 17489575 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.