Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0.354 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 0.354 | 0.354 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0.354 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 0.354 | 0.354 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 1 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0012 | 0.354 | 0.354 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.354 | 0.354 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0022 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0012 | 0.354 | 0.354 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.354 | 0.354 |
Toxoplasma gondii | exonuclease III APE | 0.0022 | 1 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0012 | 0.354 | 0.354 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0022 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 0.354 | 0.354 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 1 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0012 | 0.354 | 0.354 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 1 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 1 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 0.354 | 0.354 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0022 | 1 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0022 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | nuclear hormone receptor | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.354 | 0.354 |
Brugia malayi | ecdysteroid receptor | 0.0012 | 0.354 | 0.354 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 1 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.354 | 0.354 |
Brugia malayi | steroid hormone receptor | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 1 | 1 |
Onchocerca volvulus | 0.0012 | 0.354 | 0.5 | |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0022 | 1 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.354 | 0.354 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0.354 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0022 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 0.354 | 0.354 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 1 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0012 | 0.354 | 0.354 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antifungal activity against Candida albicans ATCC 14053 at 100 ug/disk | ChEMBL. | 18163662 | |
Activity (functional) | 0 | Antibacterial activity against Staphylococcus aureus ATCC 25923 at 100 ug/disk | ChEMBL. | 18163662 |
Activity (functional) | 0 | Antibacterial activity against Bacillus subtilis ATCC 6051 at 100 ug/disk | ChEMBL. | 18163662 |
Activity (functional) | 0 | Antifungal activity against Candida albicans ATCC 14053 at 100 ug/disk | ChEMBL. | 18163662 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.