Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Homo sapiens | diacylglycerol lipase, alpha | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | lipase | 0.0173 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0173 | 0.5 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0173 | 0.5 | 0.5 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0173 | 0.5 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0173 | 0.5 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0173 | 0.5 | 0.5 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0173 | 0.5 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0173 | 0.5 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0173 | 0.5 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0173 | 0.5 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0173 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 100 uM | Agonist activity at human TRPV1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux | ChEMBL. | 18424134 |
EC50 (functional) | > 100 uM | Agonist activity at rat TRPA1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux | ChEMBL. | 18424134 |
EC50 (functional) | > 100 uM | Agonist activity at human TRPV1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux | ChEMBL. | 18424134 |
EC50 (functional) | > 100 uM | Agonist activity at rat TRPA1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux | ChEMBL. | 18424134 |
Efficacy (functional) | = 0 % | Agonist activity at rat TRPA1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux at 100 uM relative to mustard oil | ChEMBL. | 18424134 |
Efficacy (functional) | = 0 % | Agonist activity at rat TRPA1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux at 100 uM relative to mustard oil | ChEMBL. | 18424134 |
Efficacy (functional) | = 7.7 % | Agonist activity at human TRPV1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux at 10 uM relative to ionomycin | ChEMBL. | 18424134 |
Efficacy (functional) | = 7.7 % | Agonist activity at human TRPV1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux at 10 uM relative to ionomycin | ChEMBL. | 18424134 |
IC50 (binding) | > 10 uM | Inhibition of human MAGL mediated [14C]2-AG hydrolysis in COS cell | ChEMBL. | 18424134 |
IC50 (binding) | > 10 uM | Inhibition of human DAGLalpha mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG in COS cell | ChEMBL. | 18424134 |
IC50 (binding) | > 10 uM | Inhibition of human DAGLalpha mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG in COS cell | ChEMBL. | 18424134 |
IC50 (functional) | = 12.5 uM | Inhibition of [14C]anandamide uptake in rat RBL-2H3 | ChEMBL. | 18424134 |
IC50 (binding) | > 50 uM | Inhibition of rat brain FAAH mediated [14C]anandamide hydrolysis | ChEMBL. | 18424134 |
IC50 (binding) | > 50 uM | Inhibition of rat brain FAAH mediated [14C]anandamide hydrolysis | ChEMBL. | 18424134 |
Ki (binding) | > 10 uM | Binding affinity to human CB1 receptor expressed in COS cells | ChEMBL. | 18424134 |
Ki (binding) | > 10 uM | Binding affinity to human CB2 receptor expressed in COS cells | ChEMBL. | 18424134 |
Ki (binding) | > 10 uM | Binding affinity to human CB1 receptor expressed in COS cells | ChEMBL. | 18424134 |
Ki (binding) | > 10 uM | Binding affinity to human CB2 receptor expressed in COS cells | ChEMBL. | 18424134 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.