Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | diacylglycerol lipase, alpha | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0173 | 0.9206 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0173 | 0.9206 | 0.9206 |
Brugia malayi | Lipase family protein | 0.0173 | 0.9206 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0173 | 0.9206 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | lipase | 0.0173 | 0.9206 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0 | 0.5 |
Onchocerca volvulus | 0.0173 | 0.9206 | 0.5 | |
Trypanosoma brucei | lipase domain protein, putative | 0.0173 | 0.9206 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0186 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 1 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0173 | 0.9206 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0173 | 0.9206 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0173 | 0.9206 | 0.9206 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0173 | 0.9206 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0173 | 0.9206 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 100 uM | Agonist activity at human TRPV1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux | ChEMBL. | 18424134 |
EC50 (functional) | > 100 uM | Agonist activity at rat TRPA1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux | ChEMBL. | 18424134 |
EC50 (functional) | > 100 uM | Agonist activity at human TRPV1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux | ChEMBL. | 18424134 |
EC50 (functional) | > 100 uM | Agonist activity at rat TRPA1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux | ChEMBL. | 18424134 |
Efficacy (functional) | = 4.7 % | Agonist activity at human TRPV1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux at 10 uM relative to ionomycin | ChEMBL. | 18424134 |
Efficacy (functional) | = 4.7 % | Agonist activity at human TRPV1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux at 10 uM relative to ionomycin | ChEMBL. | 18424134 |
Efficacy (functional) | = 50.8 % | Agonist activity at rat TRPA1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux at 100 uM relative to mustard oil | ChEMBL. | 18424134 |
Efficacy (functional) | = 50.8 % | Agonist activity at rat TRPA1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux at 100 uM relative to mustard oil | ChEMBL. | 18424134 |
IC50 (binding) | > 10 uM | Inhibition of human MAGL mediated [14C]2-AG hydrolysis in COS cell | ChEMBL. | 18424134 |
IC50 (binding) | > 10 uM | Inhibition of human DAGLalpha mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG in COS cell | ChEMBL. | 18424134 |
IC50 (binding) | > 10 uM | Inhibition of human DAGLalpha mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG in COS cell | ChEMBL. | 18424134 |
IC50 (functional) | > 25 uM | Inhibition of [14C]anandamide uptake in rat RBL-2H3 | ChEMBL. | 18424134 |
IC50 (binding) | > 50 uM | Inhibition of rat brain FAAH mediated [14C]anandamide hydrolysis | ChEMBL. | 18424134 |
IC50 (binding) | > 50 uM | Inhibition of rat brain FAAH mediated [14C]anandamide hydrolysis | ChEMBL. | 18424134 |
Ki (binding) | = 7.7 uM | Binding affinity to human CB2 receptor expressed in COS cells | ChEMBL. | 18424134 |
Ki (binding) | = 7.7 uM | Binding affinity to human CB2 receptor expressed in COS cells | ChEMBL. | 18424134 |
Ki (binding) | > 10 uM | Binding affinity to human CB1 receptor expressed in COS cells | ChEMBL. | 18424134 |
Ki (binding) | > 10 uM | Binding affinity to human CB1 receptor expressed in COS cells | ChEMBL. | 18424134 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.