Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Homo sapiens | diacylglycerol lipase, alpha | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Homo sapiens | transient receptor potential cation channel, subfamily V, member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Kringle domain containing protein | 0.0025 | 0.0481 | 0.0481 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0025 | 0.0481 | 0.0481 |
Toxoplasma gondii | kringle domain-containing protein | 0.0025 | 0.0481 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0173 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.6361 | 0.6361 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0173 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0025 | 0.0481 | 0.0481 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.6361 | 0.6361 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0173 | 1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0173 | 1 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0025 | 0.0481 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0173 | 1 | 1 |
Onchocerca volvulus | 0.0116 | 0.6361 | 0.6361 | |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0481 | 0.0757 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0025 | 0.0481 | 0.0481 |
Brugia malayi | Trypsin family protein | 0.0116 | 0.6361 | 0.6361 |
Trypanosoma brucei | lipase domain protein, putative | 0.0173 | 1 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0025 | 0.0481 | 0.5 |
Onchocerca volvulus | 0.0025 | 0.0481 | 0.0481 | |
Trichomonas vaginalis | lipase containing protein, putative | 0.0173 | 1 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0173 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0116 | 0.6361 | 1 |
Onchocerca volvulus | 0.0099 | 0.5252 | 0.5252 | |
Loa Loa (eye worm) | lipase | 0.0173 | 1 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0173 | 1 | 1 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0025 | 0.0481 | 0.0481 |
Onchocerca volvulus | 0.0173 | 1 | 1 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0116 | 0.6361 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0481 | 0.0481 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 10 uM | Agonist activity at human TRPV1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux | ChEMBL. | 18424134 |
EC50 (functional) | = 10 uM | Agonist activity at human TRPV1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux | ChEMBL. | 18424134 |
EC50 (functional) | = 26.3 uM | Agonist activity at rat TRPA1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux | ChEMBL. | 18424134 |
EC50 (functional) | = 26.3 uM | Agonist activity at rat TRPA1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux | ChEMBL. | 18424134 |
Efficacy (functional) | = 20.7 % | Agonist activity at human TRPV1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux at 10 uM relative to ionomycin | ChEMBL. | 18424134 |
Efficacy (functional) | = 20.7 % | Agonist activity at human TRPV1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux at 10 uM relative to ionomycin | ChEMBL. | 18424134 |
Efficacy (functional) | = 136 % | Agonist activity at rat TRPA1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux at 100 uM relative to mustard oil | ChEMBL. | 18424134 |
Efficacy (functional) | = 136 % | Agonist activity at rat TRPA1 channel expressed in human HEK293 cells assessed as elevation in intracellular calcium flux at 100 uM relative to mustard oil | ChEMBL. | 18424134 |
IC50 (binding) | > 10 uM | Inhibition of human MAGL mediated [14C]2-AG hydrolysis in COS cell | ChEMBL. | 18424134 |
IC50 (binding) | > 10 uM | Inhibition of human DAGLalpha mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG in COS cell | ChEMBL. | 18424134 |
IC50 (binding) | > 10 uM | Inhibition of human DAGLalpha mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG in COS cell | ChEMBL. | 18424134 |
IC50 (functional) | > 25 uM | Inhibition of [14C]anandamide uptake in rat RBL-2H3 | ChEMBL. | 18424134 |
IC50 (binding) | > 50 uM | Inhibition of rat brain FAAH mediated [14C]anandamide hydrolysis | ChEMBL. | 18424134 |
IC50 (binding) | > 50 uM | Inhibition of rat brain FAAH mediated [14C]anandamide hydrolysis | ChEMBL. | 18424134 |
Ki (binding) | = 1.6 uM | Binding affinity to human CB1 receptor expressed in COS cells | ChEMBL. | 18424134 |
Ki (binding) | = 1.6 uM | Binding affinity to human CB1 receptor expressed in COS cells | ChEMBL. | 18424134 |
Ki (binding) | = 4.7 uM | Binding affinity to human CB2 receptor expressed in COS cells | ChEMBL. | 18424134 |
Ki (binding) | = 4.7 uM | Binding affinity to human CB2 receptor expressed in COS cells | ChEMBL. | 18424134 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.