Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | hydroxysteroid 11-beta dehydrogenase 1 | Starlite/ChEMBL | References |
Mus musculus | hydroxysteroid 11-beta dehydrogenase 2 | Starlite/ChEMBL | References |
Homo sapiens | hydroxysteroid (11-beta) dehydrogenase 1 | Starlite/ChEMBL | References |
Homo sapiens | hydroxysteroid (11-beta) dehydrogenase 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | short chain dehydrogenase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Mycobacterium tuberculosis | Probable oxidoreductase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxysteroid 11-beta dehydrogenase 1 | 292 aa | 246 aa | 25.2 % |
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxysteroid (11-beta) dehydrogenase 1 | 292 aa | 250 aa | 24.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0493 | 0.5476 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0493 | 0.5476 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0493 | 0.5476 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0493 | 0.5476 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0493 | 0.5476 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0493 | 0.5476 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0493 | 0.5476 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0493 | 0.5476 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0493 | 0.5476 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0493 | 0.5476 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0493 | 0.5476 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0493 | 0.5476 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0493 | 0.5476 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0685 | 1 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0493 | 0.5476 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0493 | 0.5476 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0493 | 0.5476 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0493 | 0.5476 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0493 | 0.5476 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0493 | 0.5476 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0493 | 0.5476 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0493 | 0.5476 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0493 | 0.5476 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0493 | 0.5476 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0493 | 0.5476 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0493 | 0.5476 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0493 | 0.5476 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0493 | 0.5476 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0493 | 0.5476 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0493 | 0.5476 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0493 | 0.5476 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0493 | 0.5476 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0493 | 0.5476 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0493 | 0.5476 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0493 | 0.5476 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0493 | 0.5476 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0493 | 0.5476 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0493 | 0.5476 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0493 | 0.5476 | 1 |
Onchocerca volvulus | 0.0493 | 0.5476 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0493 | 0.5476 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0493 | 0.5476 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0493 | 0.5476 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0493 | 0.5476 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0493 | 0.5476 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0493 | 0.5476 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0493 | 0.5476 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0493 | 0.5476 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0493 | 0.5476 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0493 | 0.5476 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0493 | 0.5476 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0493 | 0.5476 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0493 | 0.5476 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0493 | 0.5476 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0493 | 0.5476 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0493 | 0.5476 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0493 | 0.5476 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0493 | 0.5476 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0493 | 0.5476 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0493 | 0.5476 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0493 | 0.5476 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0493 | 0.5476 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0493 | 0.5476 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0493 | 0.5476 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0493 | 0.5476 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0493 | 0.5476 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0493 | 0.5476 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0493 | 0.5476 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0493 | 0.5476 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0493 | 0.5476 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0493 | 0.5476 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0493 | 0.5476 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 22 nM | Inhibition of human 11betaHSD1 by SPA assay | ChEMBL. | 18440812 |
IC50 (binding) | = 22 nM | Inhibition of human 11betaHSD1 by SPA assay | ChEMBL. | 18440812 |
IC50 (binding) | = 38 nM | Inhibition of mouse 11betaHSD1 by SPA assay | ChEMBL. | 18440812 |
IC50 (binding) | = 38 nM | Inhibition of mouse 11betaHSD1 by SPA assay | ChEMBL. | 18440812 |
IC50 (binding) | > 4000 nM | Inhibition of human 11betaHSD2 by SPA assay | ChEMBL. | 18440812 |
IC50 (binding) | > 4000 nM | Inhibition of mouse 11betaHSD2 by SPA assay | ChEMBL. | 18440812 |
IC50 (binding) | > 4000 nM | Inhibition of human 11betaHSD2 by SPA assay | ChEMBL. | 18440812 |
IC50 (binding) | > 4000 nM | Inhibition of mouse 11betaHSD2 by SPA assay | ChEMBL. | 18440812 |
Inhibition (functional) | Inhibition of 11betaHSD1 in mouse phamacodynamic model assessed as inhibition of [3H]cortisone to [3H]cortisol at 10 mg/kg, po after 4 hrs | ChEMBL. | 18440812 | |
Inhibition (functional) | Inhibition of 11betaHSD1 in mouse phamacodynamic model assessed as inhibition of [3H]cortisone to [3H]cortisol at 10 mg/kg, po after 1 hr | ChEMBL. | 18440812 | |
Inhibition (functional) | 0 | Inhibition of 11betaHSD1 in mouse phamacodynamic model assessed as inhibition of [3H]cortisone to [3H]cortisol at 10 mg/kg, po after 1 hr | ChEMBL. | 18440812 |
Inhibition (functional) | 0 | Inhibition of 11betaHSD1 in mouse phamacodynamic model assessed as inhibition of [3H]cortisone to [3H]cortisol at 10 mg/kg, po after 4 hrs | ChEMBL. | 18440812 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.