Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carbonic anhydrase II | 0.1194 | 0.6863 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0546 | 0.2921 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1194 | 0.6863 | 0.6508 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0546 | 0.2921 | 0.3258 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0956 | 0.5417 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0069 | 0.0016 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0546 | 0.2921 | 0.3258 |
Toxoplasma gondii | hypothetical protein | 0.0546 | 0.2921 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.1194 | 0.6863 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1194 | 0.6863 | 0.6508 |
Echinococcus granulosus | carbonic anhydrase | 0.0546 | 0.2921 | 0.4243 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0546 | 0.2921 | 0.3258 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1194 | 0.6863 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0546 | 0.2921 | 0.212 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1393 | 0.8075 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1194 | 0.6863 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0546 | 0.2921 | 0.3258 |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.0069 | 0.0016 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1194 | 0.6863 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1194 | 0.6863 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1194 | 0.6863 | 0.7647 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1393 | 0.8075 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1586 | 0.9251 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1393 | 0.8075 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.1393 | 0.8075 | 1 |
Onchocerca volvulus | 0.0201 | 0.0817 | 1 | |
Mycobacterium ulcerans | carbonic anhydrase | 0.1586 | 0.9251 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0546 | 0.2921 | 0.4243 |
Loa Loa (eye worm) | hypothetical protein | 0.0546 | 0.2921 | 0.212 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0763 | 0.4241 | 0.7823 |
Echinococcus granulosus | carbonic anhydrase | 0.0546 | 0.2921 | 0.4243 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0862 | 0.4841 | 0.8935 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0546 | 0.2921 | 0.3258 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1586 | 0.9251 | 1 |
Onchocerca volvulus | Putative sulfate transporter | 0.0201 | 0.0817 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0546 | 0.2921 | 0.212 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1194 | 0.6863 | 0.7647 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0232 | 0.1007 | 0.1835 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1194 | 0.6863 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1393 | 0.8075 | 0.8729 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0232 | 0.1007 | 0.1247 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Reversal of haloperidol-induced hypolocomotion in mouse at 30 mg/kg, ip | ChEMBL. | 18407496 | |
Activity (functional) | Antagonist activity at human recombinant adenosine A2A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR assay | ChEMBL. | 18407496 | |
Activity (functional) | 0 | Reversal of haloperidol-induced hypolocomotion in mouse at 30 mg/kg, ip | ChEMBL. | 18407496 |
Activity (functional) | 0 | Antagonist activity at human recombinant adenosine A2A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR assay | ChEMBL. | 18407496 |
EC50 (functional) | > 10 uM | Agonist activity at human recombinant adenosine A2A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR assay | ChEMBL. | 18407496 |
EC50 (functional) | > 10 uM | Agonist activity at human recombinant adenosine A2A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR assay | ChEMBL. | 18407496 |
Ki (binding) | = 20 nM | Binding affinity at human adenosine A2A receptor | ChEMBL. | 18407496 |
Ki (binding) | = 20 nM | Binding affinity at human adenosine A2A receptor | ChEMBL. | 18407496 |
Ki (binding) | = 615 nM | Binding affinity at human adenosine A1 receptor | ChEMBL. | 18407496 |
Ki (binding) | = 615 nM | Binding affinity at human adenosine A1 receptor | ChEMBL. | 18407496 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.