Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Integrase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0131 | 0.5092 | 0.9053 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0629 | 0.028 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.209 | 0.2963 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0397 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0142 | 0.5559 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.209 | 0.2963 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.209 | 0.2963 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.209 | 0.2963 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0397 | 0.0456 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.209 | 0.2403 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.5092 | 0.9053 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.209 | 0.3347 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0397 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.209 | 0.2403 |
Trypanosoma brucei | RNA helicase, putative | 0.0125 | 0.4824 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0212 | 0.8698 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.209 | 0.204 |
Brugia malayi | Pre-SET motif family protein | 0.0212 | 0.8698 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.209 | 0.2963 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0629 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0629 | 0.011 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0397 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0142 | 0.5559 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0397 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0397 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0629 | 0.0723 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.209 | 0.204 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0131 | 0.5092 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0629 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.209 | 0.204 |
Brugia malayi | RNA binding protein | 0.0063 | 0.209 | 0.2403 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.4824 | 0.8508 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0027 | 0.0462 | 0.0078 |
Schistosoma mansoni | thyroid hormone receptor | 0.0142 | 0.5559 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0242 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.209 | 0.2963 |
Brugia malayi | Cytochrome P450 family protein | 0.0027 | 0.0462 | 0.0531 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CIC95 (functional) | = 1 uM | Antiviral activity against HIV1 3b in human MT4 cells assessed as inhibition of viral spread in presence of 10% heat-inactivated fetal bovine serum | ChEMBL. | 18362069 |
CIC95 (functional) | > 1 uM | Antiviral activity against HIV1 3b in human MT4 cells assessed as inhibition of viral spread in presence of 50% normal human serum | ChEMBL. | 18362069 |
IC50 (binding) | = 0.02 uM | Inhibition of HIV1 recombinant integrase strand transfer activity | ChEMBL. | 18362069 |
IC50 (binding) | = 0.02 uM | Inhibition of HIV1 recombinant integrase strand transfer activity | ChEMBL. | 18362069 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.