Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0142 | 0.5791 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0163 | 0.5 |
Echinococcus multilocularis | jun protein | 0.0175 | 0.7516 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0163 | 0.5 |
Trypanosoma cruzi | membrane transporter protein, putative | 0.0035 | 0.0163 | 0.5 |
Trypanosoma brucei | membrane transporter protein, putative | 0.0035 | 0.0163 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0163 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 1 | 1 |
Trypanosoma brucei | membrane transporter protein, putative | 0.0035 | 0.0163 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0163 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0175 | 0.7516 | 1 |
Echinococcus granulosus | jun protein | 0.0175 | 0.7516 | 1 |
Brugia malayi | bZIP transcription factor family protein | 0.0175 | 0.7516 | 0.4433 |
Schistosoma mansoni | jun-related protein | 0.0142 | 0.5791 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0163 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0175 | 0.7516 | 1 |
Trypanosoma brucei | membrane transporter protein, putative | 0.0035 | 0.0163 | 0.5 |
Echinococcus multilocularis | multidrug and toxin extrusion protein 2 | 0.0035 | 0.0163 | 0.0217 |
Trypanosoma brucei | MATE efflux family protein, putative | 0.0035 | 0.0163 | 0.5 |
Onchocerca volvulus | 0.0137 | 0.5538 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0163 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0163 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 9.4 uM | Antiproliferative activity against PDGF-induced rat aortic VSMC by colorimetric assay | ChEMBL. | 18400498 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.