Detailed view for TcCLB.507011.20

Basic information

TDR Targets ID: 41108
Trypanosoma cruzi, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.7936 | Length (AA): 473 | MW (Da): 52126 | Paralog Number: 5

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 11

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01554   MatE

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0015297   antiporter activity  
GO:0015238   drug transporter activity  
GO:0055085   transmembrane transport  
GO:0006855   multidrug transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 456 1ar1 (A) 61 518 12.00 0.00000013 0.02 1.08 -1.09
31 421 2b2h (A) 5 360 10.00 0.000098 0.02 0.96 -1.89
27 459 5yck (A) 22 458 27.00 0 1 1.30193 -0.45
28 468 5yck (A) 26 467 21.00 0.00000036 1 1.24185 -0.42
32 467 5yck (A) 30 466 18.00 0 0.99 1.21918 -0.45
47 456 2cfq (A) 12 414 16.00 0 0.12 0.789208 1.15
264 322 3k0w (A) 200 254 33.00 0.45 0.05 0.145236 2.36

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_126647)

Species Accession Gene Product
Arabidopsis thaliana AT1G71870   MATE efflux family protein
Arabidopsis thaliana AT1G73700   MATE efflux family protein
Arabidopsis thaliana AT5G49130   MATE efflux family protein
Arabidopsis thaliana AT2G34360   MATE efflux family protein
Arabidopsis thaliana AT5G52450   MATE efflux family protein
Arabidopsis thaliana AT4G29140   putative MATE transport protein ADS1
Arabidopsis thaliana AT5G19700   MATE efflux family protein
Candida albicans CaO19.7648   potential Multi Antimicrobial Extrusion (MATE) family drug/sodium antiporter
Candida albicans CaO19_6691   hypothetical protein
Candida albicans CaO19.9620   potential Multi Antimicrobial Extrusion (MATE) family drug/sodium antiporter
Candida albicans CaO19.13444   potential Multi Antimicrobial Extrusion (MATE) family drug/sodium antiporter
Candida albicans CaO19.6691   potential Multi Antimicrobial Extrusion (MATE) family drug/sodium antiporter
Candida albicans CaO19.13983   potential Multi Antimicrobial Extrusion (MATE) family drug/sodium antiporter
Candida albicans CaO19.6023   potential Multi Antimicrobial Extrusion (MATE) family drug/sodium antiporter
Candida albicans CaO19.2073   potential Multi Antimicrobial Extrusion (MATE) family drug/sodium antiporter
Dictyostelium discoideum DDB_G0278161   multi antimicrobial extrusion family protein
Dictyostelium discoideum DDB_G0292132   multi antimicrobial extrusion family protein
Escherichia coli b1985   putative multdrug exporter, MATE family
Escherichia coli b1663   multidrug efflux system transporter
Echinococcus granulosus EgrG_000846600   multidrug and toxin extrusion protein 2
Echinococcus multilocularis EmuJ_000846600   multidrug and toxin extrusion protein 2
Echinococcus multilocularis EmuJ_000650900   Multi antimicrobial extrusion protein MatE
Homo sapiens 101060602   multidrug and toxin extrusion protein 2-like
Homo sapiens ENSG00000142494   solute carrier family 47 (multidrug and toxin extrusion), member 1
Homo sapiens ENSG00000180638   solute carrier family 47 (multidrug and toxin extrusion), member 2
Leishmania braziliensis LbrM.34.3600   hypothetical protein, conserved
Leishmania braziliensis LbrM.34.3590   hypothetical protein, conserved
Leishmania donovani LdBPK_353630.1   hypothetical protein, conserved
Leishmania donovani LdBPK_353680.1   hypothetical protein, conserved
Leishmania infantum LinJ.35.3630   hypothetical protein, conserved
Leishmania infantum LinJ.35.3680   hypothetical protein, conserved
Leishmania major LmjF.35.3580   hypothetical protein, conserved
Leishmania major LmjF.35.3630   hypothetical protein, conserved
Leishmania mexicana LmxM.34.3630   hypothetical protein, conserved
Leishmania mexicana LmxM.34.3580   hypothetical protein, conserved
Mus musculus ENSMUSG00000010122   solute carrier family 47, member 1
Mus musculus ENSMUSG00000069855   solute carrier family 47, member 2
Oryza sativa 4341093   Os06g0494400
Oryza sativa 4341096   Os06g0495500
Oryza sativa 4342011   Os06g0707100
Oryza sativa 4348368   Os10g0344900
Oryza sativa 4348369   Os10g0345100
Oryza sativa 4334722   Os03g0839200
Oryza sativa 4335602   Os04g0373400
Saccharomyces cerevisiae YDR338C   hypothetical protein
Saccharomyces cerevisiae YHR032W   Erc1p
Schistosoma japonicum Sjp_0308610   Multidrug and toxin extrusion protein 1, putative
Schistosoma japonicum Sjp_0093640   Multidrug and toxin extrusion protein 1, putative
Schistosoma mansoni Smp_135490   multidrug resistance protein
Schmidtea mediterranea mk4.004103.00  
Schmidtea mediterranea mk4.018668.00   Multidrug and toxin extrusion protein
Schmidtea mediterranea mk4.010450.02   Multidrug and toxin extrusion protein
Schmidtea mediterranea mk4.007185.02   Multidrug and toxin extrusion protein
Schmidtea mediterranea mk4.000920.06   Multidrug and toxin extrusion protein
Schmidtea mediterranea mk4.027228.00   Multidrug and toxin extrusion protein
Schmidtea mediterranea mk4.015276.00   Multidrug and toxin extrusion protein
Schmidtea mediterranea mk4.030245.00   Multidrug and toxin extrusion protein
Schmidtea mediterranea mk4.021159.00   Multidrug and toxin extrusion protein
Schmidtea mediterranea mk4.017515.02   Multidrug and toxin extrusion protein
Schmidtea mediterranea mk4.019589.00   Multidrug and toxin extrusion protein
Schmidtea mediterranea mk4.007493.02  
Schmidtea mediterranea mk4.018380.03   Multidrug and toxin extrusion protein
Schmidtea mediterranea mk4.001634.01   Multidrug and toxin extrusion protein
Schmidtea mediterranea mk4.000920.05  
Schmidtea mediterranea mk4.028791.00   Multidrug and toxin extrusion protein
Trypanosoma brucei gambiense Tbg972.9.7030   membrane transporter protein, putative
Trypanosoma brucei gambiense Tbg972.9.7060   membrane transporter protein, putative
Trypanosoma brucei gambiense Tbg972.9.7050   hypothetical protein, conserved,membrane transporter protein, putative
Trypanosoma brucei gambiense Tbg972.5.3450   membrane transporter protein, putative
Trypanosoma brucei gambiense Tbg972.5.3460   membrane transporter protein, putative
Trypanosoma brucei gambiense Tbg972.5.6540   membrane transporter protein, putative
Trypanosoma brucei gambiense Tbg972.9.7040   hypothetical protein, conserved,membrane transporter protein, putative
Trypanosoma brucei Tb927.5.2430   membrane transporter protein, putative
Trypanosoma brucei Tb927.9.11790   membrane transporter protein, putative
Trypanosoma brucei Tb927.9.11810   membrane transporter protein, putative
Trypanosoma brucei Tb927.9.11800   MATE efflux family protein, putative
Trypanosoma congolense TcIL3000_0_56980   hypothetical protein
Trypanosoma congolense TcIL3000_9_4800   membrane transporter protein, putative
Trypanosoma congolense TcIL3000_0_56990   membrane transporter protein, putative
Trypanosoma congolense TcIL3000_5_2320   membrane transporter protein, putative
Trypanosoma cruzi TcCLB.510667.20   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.507087.60   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.507011.10   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.510667.14   membrane transporter protein, putative
Trypanosoma cruzi TcCLB.507011.20   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511305.40   hypothetical protein, conserved

Essentiality

TcCLB.507011.20 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.2910 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.2910 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.211.2910 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.211.2910 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb09.211.2900 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.2900 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb09.211.2900 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb09.211.2900 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.5.2430 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.5.2430 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.5.2430 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.5.2430 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb09.211.2920 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.2920 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.211.2920 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.211.2920 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
b1663 Escherichia coli non-essential goodall
b1985 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens solute carrier family 47 (multidrug and toxin extrusion), member 2 Compounds References
Mus musculus solute carrier family 47, member 1 Compounds References
Escherichia coli multidrug efflux system transporter Compounds References
Homo sapiens solute carrier family 47 (multidrug and toxin extrusion), member 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0074 0.3594 0.5
0.0036 0.3193 0.5
0.0077 0.3837 1
0.0079 0.3778 1
0.0082 1 1
0.0035 0.2574 1
0.0039 0.254 1
0.0073 0.4165 1
0.00967238 1 1
0.0113072 0.634093 0.5
0.00565359 0.263158 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier TcCLB.507011.20 (Trypanosoma cruzi), hypothetical protein, conserved
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