Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin D2 receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | DNA (cytosine-5)-methyltransferase | 0.0022 | 0.0306 | 0.0306 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.3788 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.2362 | 0.6235 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.2362 | 0.6235 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | cytosine-specific DNA methylase, putative | 0.0022 | 0.0306 | 1 |
Leishmania major | modification methylase-like protein | 0.0022 | 0.0306 | 1 |
Onchocerca volvulus | 0.0042 | 0.3111 | 1 | |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0 | 0.5 |
Toxoplasma gondii | DNA methyltransferase 2, putative | 0.0022 | 0.0306 | 0.0306 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.2362 | 0.6235 |
Echinococcus multilocularis | DNA methyltransferase 2, putative | 0.0022 | 0.0306 | 0.0809 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.3788 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3111 | 0.8213 |
Entamoeba histolytica | DNA (cytosine-5)-methyltransferase, putative | 0.0022 | 0.0306 | 1 |
Echinococcus granulosus | disco interacting protein 2 | 0.0042 | 0.3111 | 0.8213 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.3788 | 1 |
Brugia malayi | Disco-interacting protein 2 homolog | 0.0042 | 0.3111 | 0.8213 |
Echinococcus multilocularis | disco interacting protein 2 | 0.0042 | 0.3111 | 0.8213 |
Schistosoma mansoni | DNA (cytosine-5)-methyltransferase | 0.0022 | 0.0306 | 0.0809 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.3788 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.3788 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.3788 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.3788 | 1 |
Plasmodium vivax | DNA (cytosine-5)-methyltransferase, putative | 0.0022 | 0.0306 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0093 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.3788 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | DNA methyltransferase 2, putative | 0.0022 | 0.0306 | 0.0809 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0037 | 0.2362 | 0.6235 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Toxoplasma gondii | C-5 cytosine-specific DNA methylase superfamily protein | 0.0022 | 0.0306 | 0.0306 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.2362 | 0.6235 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.3788 | 1 |
Schistosoma mansoni | disco-interacting protein 2 (dip2) | 0.0042 | 0.3111 | 0.8213 |
Brugia malayi | CXXC zinc finger family protein | 0.0037 | 0.2362 | 0.6235 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.2362 | 0.6235 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 24 nM | Antagonist activity at human CRTH2 receptor assessed as inhibiton of DK-PGD2-induced eosinophil chemotaxis | ChEMBL. | 18318469 |
IC50 (functional) | = 24 nM | Antagonist activity at human CRTH2 receptor assessed as inhibiton of DK-PGD2-induced eosinophil chemotaxis | ChEMBL. | 18318469 |
IC50 (functional) | = 48 nM | Antagonist activity at human CRTH2 receptor expressed in CHO cell membrane by [35S]GTPgammaS binding assay | ChEMBL. | 18318469 |
IC50 (functional) | = 48 nM | Antagonist activity at human CRTH2 receptor expressed in CHO cell membrane by [35S]GTPgammaS binding assay | ChEMBL. | 18318469 |
Ki (binding) | = 10 nM | Displacement of [3H]PGD2 from human CRTH2 receptor expressed in CHO cells | ChEMBL. | 18318469 |
Ki (binding) | = 10 nM | Displacement of [3H]PGD2 from human CRTH2 receptor expressed in CHO cells | ChEMBL. | 18318469 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.