Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.7193 | 0.7193 |
Schistosoma mansoni | amidase | 0.0115 | 0.3637 | 0.3637 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0251 | 1 | 1 |
Mycobacterium tuberculosis | Transcriptional regulatory protein | 0.0037 | 0 | 0.5 |
Plasmodium falciparum | transcriptional regulatory protein sir2a | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0067 | 0.1405 | 0.1405 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0039 | 0.0084 | 0.0084 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.7193 | 0.7193 |
Toxoplasma gondii | histone deacetylase SIR2 | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0067 | 0.1405 | 0.1405 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0251 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.1405 | 0.1405 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0251 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0115 | 0.3637 | 0.3637 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0115 | 0.3637 | 0.3637 |
Echinococcus granulosus | chromatin regulatory protein sir2 | 0.0251 | 1 | 1 |
Echinococcus multilocularis | chromatin regulatory protein sir2 | 0.0251 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.1405 | 0.1405 |
Brugia malayi | amidase | 0.0115 | 0.3637 | 0.3637 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0039 | 0.0084 | 0.0084 |
Trypanosoma brucei | Silent information regulator 2 related protein 1 | 0.0251 | 1 | 1 |
Loa Loa (eye worm) | transcriptional regulator | 0.0251 | 1 | 1 |
Toxoplasma gondii | histone deacetylase SIR2-like | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 3 | 0.0251 | 1 | 1 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0251 | 1 | 1 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0251 | 1 | 1 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0251 | 1 | 1 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0251 | 1 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0251 | 1 | 1 |
Mycobacterium ulcerans | NAD-dependent deacetylase | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.3637 | 0.3637 |
Echinococcus granulosus | geminin | 0.0191 | 0.7193 | 0.7193 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0115 | 0.3637 | 0.3637 |
Plasmodium falciparum | transcriptional regulatory protein sir2b | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0067 | 0.1405 | 0.1405 |
Giardia lamblia | Hypothetical protein | 0.0251 | 1 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.1405 | 0.1405 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0115 | 0.3637 | 0.3637 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0067 | 0.1405 | 0.1405 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0067 | 0.1405 | 0.1405 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 3 | 0.0251 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0191 | 0.7193 | 0.7193 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0067 | 0.1405 | 0.1405 |
Plasmodium vivax | NAD-dependent deacetylase, putative | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0115 | 0.3637 | 0.3637 |
Leishmania major | silent information regulator 2, putative | 0.0251 | 1 | 1 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0251 | 1 | 1 |
Mycobacterium ulcerans | Sir2-like regulatory protein | 0.0037 | 0 | 0.5 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0067 | 0.1405 | 0.1405 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0.161 | Agonist activity human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclase relative to NECA | ChEMBL. | 18321038 |
Activity (functional) | = 0.161 | Agonist activity human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclase relative to NECA | ChEMBL. | 18321038 |
logEC50 (functional) | = -2.029 | Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclase | ChEMBL. | 18321038 |
logEC50 (functional) | = -2.029 | Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclase | ChEMBL. | 18321038 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.