Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | protein kinase c iota type | 0.00148884 | 0.0418488 | 0.0418488 |
Trichomonas vaginalis | AGC family protein kinase | 0.000872177 | 0 | 0.5 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.004023 | 0.213825 | 0.213825 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.00409902 | 0.218984 | 0.218984 |
Trichomonas vaginalis | AGC family protein kinase | 0.000872177 | 0 | 0.5 |
Echinococcus multilocularis | protein kinase c iota type | 0.00148884 | 0.0418488 | 0.0418488 |
Schistosoma mansoni | serine/threonine protein kinase | 0.00556905 | 0.318745 | 0.318745 |
Schistosoma mansoni | serine/threonine protein kinase | 0.00154605 | 0.0457309 | 0.0457309 |
Echinococcus granulosus | protein kinase C gamma type | 0.00495238 | 0.276896 | 0.276896 |
Loa Loa (eye worm) | hypothetical protein | 0.00581114 | 0.335174 | 0.335174 |
Brugia malayi | protein kinase C II. | 0.00154605 | 0.0457309 | 0.175326 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.000872177 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042518 | 0.229352 | 0.229352 |
Toxoplasma gondii | AGC kinase | 0.000872177 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00524566 | 0.296798 | 0.296798 |
Trichomonas vaginalis | AGC family protein kinase | 0.000872177 | 0 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0100629 | 0.623715 | 0.623715 |
Loa Loa (eye worm) | hypothetical protein | 0.0156077 | 1 | 1 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0156077 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.00556905 | 0.318745 | 0.318745 |
Schistosoma mansoni | atypical protein kinase C | 0.00148884 | 0.0418488 | 0.0418488 |
Trichomonas vaginalis | AGC family protein kinase | 0.000872177 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00463966 | 0.255674 | 0.255674 |
Brugia malayi | Protein kinase c protein 2 | 0.00471568 | 0.260833 | 1 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.00556905 | 0.318745 | 0.318745 |
Echinococcus multilocularis | serine threonine protein kinase | 0.00495238 | 0.276896 | 0.276896 |
Entamoeba histolytica | protein kinase, putative | 0.000872177 | 0 | 0.5 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.004023 | 0.213825 | 0.213825 |
Trichomonas vaginalis | AGC family protein kinase | 0.000872177 | 0 | 0.5 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.00556905 | 0.318745 | 0.318745 |
Trichomonas vaginalis | AGC family protein kinase | 0.000872177 | 0 | 0.5 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.00154605 | 0.0457309 | 0.0457309 |
Entamoeba histolytica | protein kinase, putative | 0.000872177 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.000872177 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0156077 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.000872177 | 0 | 0.5 |
Echinococcus granulosus | protein kinase c epsilon type | 0.00154605 | 0.0457309 | 0.0457309 |
Trichomonas vaginalis | AGC family protein kinase | 0.000872177 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004023 | 0.213825 | 0.213825 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.004023 | 0.213825 | 0.213825 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.00154605 | 0.0457309 | 0.0457309 |
Entamoeba histolytica | protein kinase, putative | 0.000872177 | 0 | 0.5 |
Echinococcus granulosus | small conductance calcium activated potassium | 0.0156077 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.000872177 | 0 | 0.5 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0156077 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.000872177 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.000872177 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1314 nM | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum HB3 after 72 hrs by SYBR green 1 assay | ChEMBL. | 18345611 |
IC50 (functional) | = 1314 nM | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum HB3 after 72 hrs by SYBR green 1 assay | ChEMBL. | 18345611 |
IC50 (functional) | = 1512 nM | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum GCO3 after 72 hrs by SYBR green 1 assay | ChEMBL. | 18345611 |
IC50 (functional) | = 1512 nM | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum GCO3 after 72 hrs by SYBR green 1 assay | ChEMBL. | 18345611 |
IC50 (functional) | = 2225 nM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCB after 72 hrs by SYBR green 1 assay | ChEMBL. | 18345611 |
IC50 (functional) | = 2225 nM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCB after 72 hrs by SYBR green 1 assay | ChEMBL. | 18345611 |
IC50 (functional) | = 2550 nM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by SYBR green 1 assay | ChEMBL. | 18345611 |
IC50 (functional) | = 2550 nM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by SYBR green 1 assay | ChEMBL. | 18345611 |
Ratio IC50 (functional) | = 1.47 | Selectivity index, ratio of IC50 for chloroquine-resistant Plasmodium falciparum FCB to IC50 for chloroquine-sensitive Plasmodium falciparum GCO3 by SYBR green 1 assay | ChEMBL. | 18345611 |
Ratio IC50 (functional) | = 1.94 | Selectivity index, ratio of IC50 for chloroquine-resistant Plasmodium falciparum Dd2 to IC50 for chloroquine-sensitive Plasmodium falciparum HB3 by SYBR green 1 assay | ChEMBL. | 18345611 |
Ratio IC50 (functional) | = 1.47 | Selectivity index, ratio of IC50 for chloroquine-resistant Plasmodium falciparum FCB to IC50 for chloroquine-sensitive Plasmodium falciparum GCO3 by SYBR green 1 assay | ChEMBL. | 18345611 |
Ratio IC50 (functional) | = 1.94 | Selectivity index, ratio of IC50 for chloroquine-resistant Plasmodium falciparum Dd2 to IC50 for chloroquine-sensitive Plasmodium falciparum HB3 by SYBR green 1 assay | ChEMBL. | 18345611 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 18345611 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.