Detailed information for compound 512639

Basic information

Technical information
  • TDR Targets ID: 512639
  • Name: 5-tert-butyl-N-[1-(2,4,6-trichlorobenzoyl)pyr azol-4-yl]-4,5,6,7-tetrahydro-1,2-benzoxazole -3-carboxamide
  • MW: 495.786 | Formula: C22H21Cl3N4O3
  • H donors: 1 H acceptors: 4 LogP: 5.94 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cc(Cl)c(c(c1)Cl)C(=O)n1ncc(c1)NC(=O)c1noc2c1CC(CC2)C(C)(C)C
  • InChi: 1S/C22H21Cl3N4O3/c1-22(2,3)11-4-5-17-14(6-11)19(28-32-17)20(30)27-13-9-26-29(10-13)21(31)18-15(24)7-12(23)8-16(18)25/h7-11H,4-6H2,1-3H3,(H,27,30)
  • InChiKey: OMJAJFDTJSLAQK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-tert-butyl-N-[1-[oxo-(2,4,6-trichlorophenyl)methyl]-4-pyrazolyl]-4,5,6,7-tetrahydro-1,2-benzoxazole-3-carboxamide
  • 5-tert-butyl-N-[1-(2,4,6-trichlorophenyl)carbonylpyrazol-4-yl]-4,5,6,7-tetrahydro-1,2-benzoxazole-3-carboxamide
  • 5-tert-butyl-N-[1-(2,4,6-trichlorobenzoyl)pyrazol-4-yl]-4,5,6,7-tetrahydroindoxazene-3-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0038 0.0485 0.0485
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0038 0.0485 0.0485
Schistosoma mansoni tubulin subunit beta 0.0113 0.2263 0.2263
Toxoplasma gondii beta-1 tubulin, putative 0.0113 0.2263 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Loa Loa (eye worm) beta-tubulin 0.0113 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Echinococcus granulosus neuropeptides capa receptor 0.0038 0.0485 0.0485
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0038 0.0485 0.0485
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0038 0.0485 0.0485
Leishmania major beta tubulin 0.0113 0.2263 0.5
Echinococcus multilocularis fmrfamide receptor 0.0038 0.0485 0.0485
Echinococcus granulosus neuropeptide receptor 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0128 0.2611 0.2611
Echinococcus multilocularis neuropeptide Y receptor 0.0038 0.0485 0.0485
Brugia malayi Tachykinin-like peptides receptor 99D 0.0038 0.0485 0.0485
Onchocerca volvulus 0.0038 0.0485 0.0485
Echinococcus multilocularis neuropeptide receptor 0.0038 0.0485 0.0485
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0485 0.0485
Echinococcus multilocularis neuropeptides capa receptor 0.0038 0.0485 0.0485
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0038 0.0485 0.0485
Brugia malayi Cell death protein 3 precursor 0.0128 0.2611 0.2611
Leishmania major beta tubulin 0.0113 0.2263 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0038 0.0485 0.0485
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0439 1 1
Schistosoma mansoni biogenic amine receptor 0.0038 0.0485 0.0485
Brugia malayi hypothetical protein 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Schistosoma mansoni amine GPCR 0.0038 0.0485 0.0485
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0038 0.0485 0.0485
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0038 0.0485 0.0485
Schistosoma mansoni neuropeptide f receptor 76f 0.0038 0.0485 0.0485
Echinococcus granulosus G protein coupled receptor 139 0.0038 0.0485 0.0485
Echinococcus multilocularis neuropeptide s receptor 0.0038 0.0485 0.0485
Loa Loa (eye worm) TYRA-2 protein 0.0038 0.0485 0.0485
Echinococcus granulosus somatostatin receptor 0.0038 0.0485 0.0485
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0354 0.7986 0.7986
Onchocerca volvulus 0.0038 0.0485 0.0485
Echinococcus multilocularis sex peptide receptor 0.0038 0.0485 0.0485
Echinococcus granulosus g protein coupled receptor 0.0038 0.0485 0.0485
Onchocerca volvulus 0.0038 0.0485 0.0485
Loa Loa (eye worm) melatonin receptor type 1A 0.0038 0.0485 0.0485
Echinococcus granulosus 7tm_1 domain containing protein 0.0038 0.0485 0.0485
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0038 0.0485 0.0485
Schistosoma mansoni neuropeptide receptor 0.0038 0.0485 0.0485
Brugia malayi Serotonin receptor 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Echinococcus granulosus biogenic amine 5HT receptor 0.0038 0.0485 0.0485
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0038 0.0485 0.0485
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0038 0.0485 0.0485
Onchocerca volvulus 0.0038 0.0485 0.0485
Loa Loa (eye worm) tubulin beta-2A chain 0.0113 0.2263 0.2263
Echinococcus multilocularis tubulin beta 1 chain 0.0113 0.2263 0.2263
Schistosoma mansoni myosin xvIII 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Brugia malayi G protein-coupled receptor F59B2.13 0.0038 0.0485 0.0485
Echinococcus multilocularis g-protein coupled receptor 0.0038 0.0485 0.0485
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0038 0.0485 0.0485
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0038 0.0485 0.0485
Echinococcus multilocularis tubulin subunit beta 0.0113 0.2263 0.2263
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0038 0.0485 0.0485
Echinococcus multilocularis caspase 2 0.0128 0.2611 0.2611
Echinococcus multilocularis inhibitor of apoptosis protein 0.0439 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0038 0.0485 0.0485
Schistosoma mansoni hypothetical protein 0.0038 0.0485 0.0485
Leishmania major beta tubulin 0.0113 0.2263 0.5
Leishmania major beta tubulin 0.0113 0.2263 0.5
Echinococcus granulosus apoptotic protease activating factor 1 0.0128 0.2611 0.2611
Brugia malayi beta-tubulin, identical 0.0113 0.2263 0.2263
Leishmania major beta tubulin 0.0113 0.2263 0.5
Echinococcus granulosus neuropeptide receptor 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Schistosoma mansoni hypothetical protein 0.0038 0.0485 0.0485
Trichomonas vaginalis tubulin epsilon chain, putative 0.0113 0.2263 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Echinococcus multilocularis gamma secretase subunit aph 1 0.0249 0.5488 0.5488
Echinococcus granulosus tm gpcr rhodopsin 0.0038 0.0485 0.0485
Leishmania major beta tubulin 0.0113 0.2263 0.5
Echinococcus multilocularis Tubulin beta 2C chain 0.0113 0.2263 0.2263
Trichomonas vaginalis tubulin beta chain, putative 0.0113 0.2263 0.5
Brugia malayi neuropeptide F receptor 0.0038 0.0485 0.0485
Brugia malayi hypothetical protein 0.0038 0.0485 0.0485
Schistosoma mansoni growth hormone secretagogue receptor 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0485 0.0485
Echinococcus granulosus 7TM GPCR rhodopsin 0.0038 0.0485 0.0485
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Echinococcus granulosus neuropeptides capa receptor 0.0038 0.0485 0.0485
Schistosoma mansoni tubulin subunit beta 0.0113 0.2263 0.2263
Schistosoma mansoni biogenic amine (5HT) receptor 0.0038 0.0485 0.0485
Leishmania major beta tubulin 0.0113 0.2263 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Onchocerca volvulus 0.0038 0.0485 0.0485
Echinococcus multilocularis neuropeptide receptor A26 0.0038 0.0485 0.0485
Brugia malayi putative neuropeptide receptor 0.0038 0.0485 0.0485
Echinococcus granulosus Tubulin beta 2C chain 0.0113 0.2263 0.2263
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0485 0.0485
Echinococcus granulosus Tubulin beta 2C chain 0.0113 0.2263 0.2263
Loa Loa (eye worm) tubulin beta chain 0.0113 0.2263 0.2263
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0485 0.0485
Echinococcus granulosus tm gpcr rhodopsin 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Brugia malayi hypothetical protein 0.0128 0.2611 0.2611
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0038 0.0485 0.0485
Schistosoma mansoni alpha-1 adrenergic receptor 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0038 0.0485 0.0485
Loa Loa (eye worm) neuropeptide F receptor 0.0038 0.0485 0.0485
Schistosoma mansoni tubulin subunit beta 0.0113 0.2263 0.2263
Echinococcus granulosus neuropeptide Y receptor 0.0038 0.0485 0.0485
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0485 0.0485
Brugia malayi hypothetical protein 0.0038 0.0485 0.0485
Echinococcus multilocularis G protein coupled receptor 139 0.0038 0.0485 0.0485
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Trypanosoma brucei beta tubulin 0.0113 0.2263 1
Trypanosoma cruzi beta tubulin, putative 0.0113 0.2263 1
Echinococcus granulosus max protein X 0.0297 0.663 0.663
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0038 0.0485 0.0485
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0485 0.0485
Schistosoma mansoni neuropeptide receptor 0.0038 0.0485 0.0485
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0249 0.5488 0.5488
Brugia malayi G protein-coupled receptor 0.0038 0.0485 0.0485
Brugia malayi Melatonin receptor type 1A 0.0038 0.0485 0.0485
Echinococcus granulosus tubulin subunit beta 0.0113 0.2263 0.2263
Brugia malayi hypothetical protein 0.0038 0.0485 0.0485
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0485 0.0485
Onchocerca volvulus Cell death protein 3 homolog 0.0128 0.2611 0.2611
Onchocerca volvulus Neuropeptide F receptor homolog 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Loa Loa (eye worm) tubulin beta-4 chain 0.0113 0.2263 0.2263
Echinococcus multilocularis max protein X 0.0297 0.663 0.663
Giardia lamblia Beta tubulin 0.0113 0.2263 0.5
Brugia malayi hypothetical protein 0.0038 0.0485 0.0485
Schistosoma mansoni neuropeptide receptor 0.0038 0.0485 0.0485
Echinococcus granulosus Tubulin beta 2C chain 0.0113 0.2263 0.2263
Echinococcus granulosus tachykinin peptides receptor 99D 0.0038 0.0485 0.0485
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0038 0.0485 0.0485
Onchocerca volvulus 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Schistosoma mansoni gamma-secretase subunit aph-1 0.0249 0.5488 0.5488
Echinococcus granulosus beta tubulin 0.0113 0.2263 0.2263
Brugia malayi gamma-secretase subunit aph-1 0.0249 0.5488 0.5488
Trichomonas vaginalis tubulin gamma chain, putative 0.0113 0.2263 0.5
Brugia malayi AKH receptor 0.0038 0.0485 0.0485
Echinococcus granulosus Tubulin beta 2C chain 0.0113 0.2263 0.2263
Echinococcus multilocularis G-protein coupled receptor, putative 0.0038 0.0485 0.0485
Schistosoma mansoni biogenic amine (5HT) receptor 0.0038 0.0485 0.0485
Echinococcus granulosus dro:myosuppressin receptor 0.0038 0.0485 0.0485
Echinococcus multilocularis orexin receptor type 2 0.0038 0.0485 0.0485
Onchocerca volvulus 0.0038 0.0485 0.0485
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0038 0.0485 0.0485
Echinococcus granulosus tm gpcr rhodopsin 0.0038 0.0485 0.0485
Schistosoma mansoni adenoreceptor 0.0038 0.0485 0.0485
Echinococcus granulosus allatostatin A receptor 0.0038 0.0485 0.0485
Toxoplasma gondii beta-tubulin, putative 0.0113 0.2263 1
Schistosoma mansoni amine GPCR 0.0038 0.0485 0.0485
Echinococcus granulosus biogenic amine 5HT receptor 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Onchocerca volvulus 0.0439 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Schistosoma mansoni neuropeptide receptor 0.0038 0.0485 0.0485
Schistosoma mansoni hypothetical protein 0.0038 0.0485 0.0485
Schistosoma mansoni inhibitor of apoptosis protein 0.0439 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0439 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0038 0.0485 0.0485
Echinococcus granulosus g-protein coupled receptor 0.0038 0.0485 0.0485
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0485 0.0485
Schistosoma mansoni caspase-7 (C14 family) 0.0128 0.2611 0.2611
Brugia malayi sulfakinin receptor protein 0.0038 0.0485 0.0485
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0485 0.0485
Echinococcus granulosus tubulin beta 4A class IVa 0.0113 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Echinococcus granulosus alpha 1A adrenergic receptor 0.0038 0.0485 0.0485
Echinococcus granulosus fmrfamide receptor 0.0038 0.0485 0.0485
Loa Loa (eye worm) G-protein coupled receptor 0.0038 0.0485 0.0485
Trypanosoma brucei beta tubulin 0.0113 0.2263 1
Brugia malayi Tubulin beta-1 chain 0.0113 0.2263 0.2263
Leishmania major beta tubulin 0.0113 0.2263 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Onchocerca volvulus 0.0038 0.0485 0.0485
Echinococcus multilocularis Tubulin beta 2C chain 0.0113 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0128 0.2611 0.2611
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0439 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0485 0.0485
Schistosoma mansoni tubulin subunit beta 0.0113 0.2263 0.2263
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0485 0.0485
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0038 0.0485 0.0485
Leishmania major beta tubulin 0.0113 0.2263 0.5
Loa Loa (eye worm) tubulin beta-1 chain 0.0113 0.2263 0.2263
Echinococcus granulosus neuropeptide receptor A26 0.0038 0.0485 0.0485
Leishmania major beta tubulin 0.0113 0.2263 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0038 0.0485 0.0485
Echinococcus multilocularis dro:myosuppressin receptor 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0038 0.0485 0.0485
Brugia malayi Dopamine receptor protein 1 0.0038 0.0485 0.0485
Trypanosoma brucei beta tubulin 0.0113 0.2263 1
Brugia malayi hypothetical protein 0.0038 0.0485 0.0485
Leishmania major beta tubulin 0.0113 0.2263 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0038 0.0485 0.0485
Echinococcus multilocularis apoptotic protease activating factor 1 0.0128 0.2611 0.2611
Schistosoma mansoni amine GPCR 0.0038 0.0485 0.0485
Echinococcus granulosus neuropeptide FF receptor 2 0.0038 0.0485 0.0485
Echinococcus granulosus serotonin receptor 0.0038 0.0485 0.0485
Brugia malayi G-protein coupled receptor 0.0038 0.0485 0.0485
Schistosoma mansoni opsin-like receptor 0.0038 0.0485 0.0485
Echinococcus granulosus caspase 2 0.0128 0.2611 0.2611
Echinococcus granulosus inhibitor of apoptosis protein 0.0439 1 1
Echinococcus multilocularis somatostatin receptor 0.0038 0.0485 0.0485
Brugia malayi hypothetical protein 0.0038 0.0485 0.0485
Brugia malayi ORL1-like opioid receptor 0.0038 0.0485 0.0485
Echinococcus multilocularis Tubulin beta 2C chain 0.0113 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Trichomonas vaginalis tubulin alpha chain, putative 0.0113 0.2263 0.5
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0297 0.663 0.663
Brugia malayi follicle stimulating hormone receptor 0.0038 0.0485 0.0485
Echinococcus granulosus sex peptide receptor 0.0038 0.0485 0.0485
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0038 0.0485 0.0485
Loa Loa (eye worm) BEN-1 protein 0.0113 0.2263 0.2263
Echinococcus granulosus beta tubulin 0.0113 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0354 0.7986 0.7986
Echinococcus granulosus neuropeptide Y receptor 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Toxoplasma gondii beta tubulin 0.0113 0.2263 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0113 0.2263 0.2263
Schistosoma mansoni neuropeptide F-like receptor 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Loa Loa (eye worm) G-protein coupled receptor 0.0038 0.0485 0.0485
Entamoeba histolytica tubulin family protein 0.0113 0.2263 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Brugia malayi Dopamine receptor protein 2 0.0038 0.0485 0.0485
Echinococcus granulosus Tubulin beta 2C chain 0.0113 0.2263 0.2263
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0485 0.0485
Echinococcus granulosus neuropeptide s receptor 0.0038 0.0485 0.0485
Brugia malayi hypothetical protein 0.0038 0.0485 0.0485
Schistosoma mansoni biogenic amine receptor 0.0038 0.0485 0.0485
Echinococcus multilocularis Tubulin beta 2C chain 0.0113 0.2263 0.2263
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0038 0.0485 0.0485
Leishmania major beta tubulin 0.0113 0.2263 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Echinococcus multilocularis fmrfamide receptor 0.0038 0.0485 0.0485
Echinococcus multilocularis beta tubulin 0.0113 0.2263 0.2263
Echinococcus granulosus g protein coupled receptor 0.0038 0.0485 0.0485
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0439 1 1
Schistosoma mansoni opsin-like receptor 0.0038 0.0485 0.0485
Onchocerca volvulus Deterin homolog 0.0439 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0038 0.0485 0.0485
Leishmania major beta tubulin 0.0113 0.2263 0.5
Brugia malayi hypothetical protein 0.0038 0.0485 0.0485
Brugia malayi GnHR receptor homolog 0.0038 0.0485 0.0485
Onchocerca volvulus 0.0038 0.0485 0.0485
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0485 0.0485
Echinococcus multilocularis neuropeptide Y receptor 0.0038 0.0485 0.0485
Onchocerca volvulus 0.0038 0.0485 0.0485
Brugia malayi N-terminal motif family protein 0.0354 0.7986 0.7986
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0038 0.0485 0.0485
Leishmania major beta tubulin 0.0113 0.2263 0.5
Schistosoma mansoni bhlhzip transcription factor bigmax 0.0297 0.663 0.663
Loa Loa (eye worm) hypothetical protein 0.0439 1 1
Leishmania major beta tubulin 0.0113 0.2263 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0038 0.0485 0.0485
Trichomonas vaginalis tubulin epsilon chain, putative 0.0113 0.2263 0.5
Onchocerca volvulus 0.0038 0.0485 0.0485
Onchocerca volvulus 0.0038 0.0485 0.0485
Leishmania major beta tubulin 0.0113 0.2263 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0485 0.0485
Schistosoma mansoni neuropeptide F-like receptor 0.0038 0.0485 0.0485
Plasmodium vivax tubulin beta chain, putative 0.0113 0.2263 0.5
Brugia malayi larval opioid receptor 0.0038 0.0485 0.0485
Brugia malayi Dopamine receptor 0.0038 0.0485 0.0485
Onchocerca volvulus 0.0038 0.0485 0.0485
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0038 0.0485 0.0485
Onchocerca volvulus 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0038 0.0485 0.0485
Echinococcus granulosus peptide allatostatin:somatostatin 0.0038 0.0485 0.0485
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0297 0.663 0.663
Giardia lamblia Beta tubulin 0.0113 0.2263 0.5
Schistosoma mansoni hypothetical protein 0.0128 0.2611 0.2611
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Echinococcus granulosus g protein coupled receptor 0.0038 0.0485 0.0485
Onchocerca volvulus 0.0038 0.0485 0.0485
Echinococcus multilocularis serotonin receptor 0.0038 0.0485 0.0485
Schistosoma mansoni amine GPCR 0.0038 0.0485 0.0485
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0485 0.0485
Loa Loa (eye worm) neuropeptide F receptor 0.0038 0.0485 0.0485
Onchocerca volvulus 0.0038 0.0485 0.0485
Schistosoma mansoni amine GPCR 0.0038 0.0485 0.0485
Plasmodium falciparum tubulin beta chain 0.0113 0.2263 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Echinococcus granulosus tubulin beta 1 chain 0.0113 0.2263 0.2263
Loa Loa (eye worm) BEN-1 protein 0.0113 0.2263 0.2263
Schistosoma mansoni bhlhzip transcription factor bigmax 0.0297 0.663 0.663
Onchocerca volvulus 0.0038 0.0485 0.0485
Echinococcus multilocularis beta tubulin 0.0113 0.2263 0.2263
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0485 0.0485
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0038 0.0485 0.0485
Schistosoma mansoni biogenic amine receptor 0.0038 0.0485 0.0485
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0485 0.0485
Schistosoma mansoni opsin-like receptor 0.0038 0.0485 0.0485
Echinococcus multilocularis g protein coupled receptor 0.0038 0.0485 0.0485
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0038 0.0485 0.0485
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0038 0.0485 0.0485
Leishmania major beta tubulin 0.0113 0.2263 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0485 0.0485
Echinococcus multilocularis neuropeptide FF receptor 2 0.0038 0.0485 0.0485
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0038 0.0485 0.0485
Echinococcus multilocularis g protein coupled receptor 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Echinococcus multilocularis allatostatin A receptor 0.0038 0.0485 0.0485
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0113 0.2263 0.2263
Brugia malayi hypothetical protein 0.0038 0.0485 0.0485
Brugia malayi G-protein coupled receptor 0.0038 0.0485 0.0485
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0485 0.0485
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Brugia malayi RE15519p 0.0038 0.0485 0.0485
Brugia malayi neuropeptide F receptor 0.0038 0.0485 0.0485
Schistosoma mansoni hypothetical protein 0.0439 1 1
Giardia lamblia Beta tubulin 0.0113 0.2263 0.5
Echinococcus multilocularis neuropeptide receptor 0.0038 0.0485 0.0485
Schistosoma mansoni histamine h1 receptor 0.0038 0.0485 0.0485
Trypanosoma brucei beta tubulin 0.0113 0.2263 1
Onchocerca volvulus 0.0128 0.2611 0.2611
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Echinococcus granulosus rhodopsin orphan GPCR 0.0038 0.0485 0.0485
Echinococcus granulosus hypothetical protein 0.0038 0.0485 0.0485
Leishmania major beta tubulin 0.0113 0.2263 0.5
Echinococcus multilocularis g protein coupled receptor 0.0038 0.0485 0.0485
Echinococcus multilocularis serotonin receptor 0.0038 0.0485 0.0485
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Schistosoma mansoni tubulin subunit beta 0.0113 0.2263 0.2263
Echinococcus multilocularis neuropeptides capa receptor 0.0038 0.0485 0.0485
Echinococcus multilocularis rhodopsin orphan GPCR 0.0038 0.0485 0.0485
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0439 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0038 0.0485 0.0485
Schistosoma mansoni tubulin subunit beta 0.0113 0.2263 0.2263
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0038 0.0485 0.0485
Entamoeba histolytica tubulin family protein 0.0113 0.2263 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Brugia malayi Serotonin receptor 0.0038 0.0485 0.0485
Echinococcus granulosus gamma secretase subunit aph 1 0.0249 0.5488 0.5488
Trichomonas vaginalis tubulin, putative 0.0113 0.2263 0.5
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0038 0.0485 0.0485
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Echinococcus granulosus orexin receptor type 2 0.0038 0.0485 0.0485
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0038 0.0485 0.0485
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0038 0.0485 0.0485
Schistosoma mansoni hypothetical protein 0.0038 0.0485 0.0485

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) 0 Inhibition of Mycobacterium tuberculosis pantothenate synthetase ChEMBL. 18335974
Inhibition (binding) = 17 % Inhibition of Mycobacterium tuberculosis pantothenate synthetase at 100 uM ChEMBL. 18335974
Inhibition (binding) = 17 % Inhibition of Mycobacterium tuberculosis pantothenate synthetase at 100 uM ChEMBL. 18335974
Inhibition (functional) = 26 % Antibacterial activity against Mycobacterium tuberculosis at 128 uM by LORA assay ChEMBL. 18335974
Inhibition (functional) = 26 % Antibacterial activity against Mycobacterium tuberculosis at 128 uM by LORA assay ChEMBL. 18335974
Inhibition (functional) = 34 % Antibacterial activity against Mycobacterium tuberculosis at 128 uM by MABA assay ChEMBL. 18335974
Inhibition (functional) = 34 % Antibacterial activity against Mycobacterium tuberculosis at 128 uM by MABA assay ChEMBL. 18335974

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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