Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | cyclins, putative | 0.0072 | 0.0593 | 0.0708 |
Echinococcus multilocularis | cyclin b3 | 0.0072 | 0.0593 | 0.0938 |
Entamoeba histolytica | cyclin, putative | 0.0123 | 0.2088 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.3397 | 1 |
Treponema pallidum | methylated-DNA-protein-cysteine S-methyltransferase (dat) | 0.0129 | 0.2253 | 0.5 |
Trichomonas vaginalis | cyclin A, putative | 0.0123 | 0.2088 | 0.9073 |
Echinococcus multilocularis | cyclins | 0.0072 | 0.0593 | 0.0938 |
Echinococcus multilocularis | cyclins | 0.0072 | 0.0593 | 0.0938 |
Echinococcus granulosus | cyclins | 0.0072 | 0.0593 | 0.0938 |
Echinococcus granulosus | cyclin b3 | 0.0072 | 0.0593 | 0.0938 |
Trichomonas vaginalis | cyclins, putative | 0.0123 | 0.2088 | 0.9073 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.2088 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0123 | 0.2088 | 0.9073 |
Trichomonas vaginalis | cyclin B, putative | 0.0123 | 0.2088 | 0.9073 |
Trichomonas vaginalis | cyclin D, putative | 0.0072 | 0.0593 | 0.0708 |
Trichomonas vaginalis | cyclin B3, putative | 0.0072 | 0.0593 | 0.0708 |
Schistosoma mansoni | cyclins | 0.0072 | 0.0593 | 0.0938 |
Echinococcus multilocularis | cyclins | 0.0072 | 0.0593 | 0.0938 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0072 | 0.0593 | 0.1625 |
Echinococcus granulosus | cyclins | 0.0072 | 0.0593 | 0.0938 |
Echinococcus multilocularis | cyclins | 0.0072 | 0.0593 | 0.0938 |
Trichomonas vaginalis | methylated-DNA--protein-cysteine methyltransferase, putative | 0.0129 | 0.2253 | 1 |
Schistosoma mansoni | cyclin B3 | 0.0072 | 0.0593 | 0.0938 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0123 | 0.2088 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0123 | 0.2088 | 1 |
Echinococcus granulosus | cyclins | 0.0072 | 0.0593 | 0.0938 |
Echinococcus granulosus | geminin | 0.0167 | 0.3397 | 1 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0072 | 0.0593 | 0.0938 |
Echinococcus multilocularis | cyclins | 0.0072 | 0.0593 | 0.0938 |
Leishmania major | hypothetical protein, conserved | 0.0129 | 0.2253 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.2088 | 1 |
Mycobacterium ulcerans | methylated-DNA--protein-cysteine methyltransferase Ogt | 0.0391 | 1 | 1 |
Trypanosoma cruzi | O-6 methyl-guanine alkyl transferase, putative | 0.0129 | 0.2253 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0123 | 0.2088 | 0.9073 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.3397 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0123 | 0.2088 | 0.9073 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0123 | 0.2088 | 1 |
Echinococcus multilocularis | cyclins | 0.0072 | 0.0593 | 0.0938 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0072 | 0.0593 | 0.1625 |
Echinococcus granulosus | cyclin B3 1 | 0.0072 | 0.0593 | 0.0938 |
Echinococcus granulosus | cyclin B | 0.0123 | 0.2088 | 0.5769 |
Chlamydia trachomatis | methylated-DNA protein-cysteine methyltransferase | 0.0129 | 0.2253 | 0.5 |
Echinococcus multilocularis | cyclin B3 1 | 0.0072 | 0.0593 | 0.0938 |
Echinococcus multilocularis | cyclins | 0.0072 | 0.0593 | 0.0938 |
Plasmodium falciparum | cyclin | 0.0072 | 0.0593 | 0.5 |
Echinococcus multilocularis | cyclin B | 0.0123 | 0.2088 | 0.5769 |
Trichomonas vaginalis | cyclins, putative | 0.0123 | 0.2088 | 0.9073 |
Trypanosoma cruzi | O-6 methyl-guanine alkyl transferase, putative | 0.0129 | 0.2253 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0072 | 0.0593 | 0.0708 |
Echinococcus granulosus | cyclins | 0.0072 | 0.0593 | 0.0938 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0123 | 0.2088 | 1 |
Onchocerca volvulus | 0.0123 | 0.2088 | 0.5 | |
Trichomonas vaginalis | cyclins, putative | 0.0123 | 0.2088 | 0.9073 |
Echinococcus granulosus | cyclins | 0.0072 | 0.0593 | 0.0938 |
Trichomonas vaginalis | cyclins, putative | 0.0123 | 0.2088 | 0.9073 |
Schistosoma mansoni | cyclin B | 0.0123 | 0.2088 | 0.5769 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0072 | 0.0593 | 0.0708 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0072 | 0.0593 | 0.0938 |
Toxoplasma gondii | hypothetical protein | 0.0055 | 0.0077 | 0.5 |
Echinococcus multilocularis | geminin | 0.0167 | 0.3397 | 1 |
Trichomonas vaginalis | cyclin D, putative | 0.0072 | 0.0593 | 0.0708 |
Mycobacterium tuberculosis | Methylated-DNA--protein-cysteine methyltransferase Ogt (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltra | 0.0391 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Cell cycle arrest in mouse tsFT210 cells after 18 hrs by flow cytometry | ChEMBL. | 18321710 |
IC50 (functional) | = 55 uM | Antiproliferative activity against mouse tsFT210 cells after 48 hrs by WST-8 assay | ChEMBL. | 18321710 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.