Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0145 | 0.2058 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0126 | 0 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0145 | 0.2058 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0145 | 0.2058 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0222 | 1 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0145 | 0.2058 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0222 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0145 | 0.2058 | 0.5 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0222 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0222 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0145 | 0.2058 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0145 | 0.2058 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0145 | 0.2058 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0145 | 0.2058 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 30 uM | Cytotoxicity against mock-infected MDBK cells by LDH method | ChEMBL. | 18289862 |
EC50 (functional) | = 11 uM | Antiviral activity against BVDV infected in MDBK cells assessed as reduction in viral induced cell destruction by MTT assay | ChEMBL. | 18289862 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.