Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | cholecystokinin B receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.006 | 0.2646 | 0.2646 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.006 | 0.2646 | 0.2646 |
Entamoeba histolytica | hypothetical protein | 0.006 | 0.2646 | 0.2646 |
Trypanosoma brucei | phosphatidylinositol 4-kinase alpha, putative | 0.0098 | 1 | 1 |
Plasmodium falciparum | phosphatidylinositol 3-kinase | 0.006 | 0.2646 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2646 | 0.2646 |
Leishmania major | phosphatidylinositol 4-kinase alpha, putative | 0.0098 | 1 | 1 |
Schistosoma mansoni | phosphatidylinositol 4-kinase | 0.0098 | 1 | 1 |
Trichomonas vaginalis | phosphatidylinositol 4-kinase, putative | 0.0098 | 1 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.006 | 0.2646 | 0.2646 |
Entamoeba histolytica | phosphatidylinositol 4-kinase, putative | 0.0098 | 1 | 1 |
Trypanosoma cruzi | phosphatidylinositol 4-kinase alpha, putative | 0.0098 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.006 | 0.2646 | 0.2646 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.006 | 0.2646 | 0.2646 |
Toxoplasma gondii | phosphatidylinositol 3- and 4-kinase | 0.006 | 0.2646 | 1 |
Plasmodium vivax | phosphatidylinositol 3-kinase, putative | 0.006 | 0.2646 | 0.5 |
Echinococcus granulosus | phosphatidylinositol 4 kinase alpha | 0.0098 | 1 | 1 |
Echinococcus multilocularis | phosphatidylinositol 4 kinase alpha | 0.0098 | 1 | 1 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.006 | 0.2646 | 0.5 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.006 | 0.2646 | 0.2646 |
Entamoeba histolytica | phosphatidylinositol-4,5-bisphosphate 3-kinase, putative | 0.006 | 0.2646 | 0.2646 |
Toxoplasma gondii | phosphatidylinositol 3- and 4-kinase | 0.006 | 0.2646 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 4-kinase type 3 alpha isoform 1 | 0.0098 | 1 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.006 | 0.2646 | 0.2646 |
Trypanosoma cruzi | phosphatidylinositol 4-kinase alpha, putative | 0.0098 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.006 | 0.2646 | 0.2646 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0098 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.006 | 0.2646 | 0.2646 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.16 uM | Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes. | ChEMBL. | 2016728 |
IC50 (binding) | = 0.16 uM | Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes. | ChEMBL. | 2016728 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.