Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0584 | 0.0584 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0584 | 0.0584 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0065 | 0.0584 | 0.0584 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0065 | 0.0584 | 0.0584 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0065 | 0.0584 | 0.0584 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0065 | 0.0584 | 0.0584 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0065 | 0.0584 | 0.0584 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0065 | 0.0584 | 0.0584 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0141 | 0.4889 | 0.4572 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0141 | 0.4889 | 0.4889 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0231 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0584 | 0.0584 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0065 | 0.0584 | 0.0584 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0231 | 1 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0065 | 0.0584 | 0.0584 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0065 | 0.0584 | 0.0584 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0065 | 0.0584 | 0.0584 |
Onchocerca volvulus | 0.0141 | 0.4889 | 1 | |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0065 | 0.0584 | 0.0584 |
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.4889 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 26 % | Displacement of [3H]AB-MECA from human adenosine A3 receptor expressed in HEK293 cells at 1 uM | ChEMBL. | 18258439 |
Activity (binding) | = 26 % | Displacement of [3H]AB-MECA from human adenosine A3 receptor expressed in HEK293 cells at 1 uM | ChEMBL. | 18258439 |
Activity (functional) | = 121 % | Activity at human adenosine A1 receptor expressed in CHO cells assessed as forskolin-stimulated cAMP production by TR-FRET assay | ChEMBL. | 18258439 |
Activity (functional) | = 121 % | Activity at human adenosine A1 receptor expressed in CHO cells assessed as forskolin-stimulated cAMP production by TR-FRET assay | ChEMBL. | 18258439 |
IC50 (functional) | = 0.15 uM | Activity at human adenosine A1 receptor expressed in CHO cells assessed as inhibition of CPA-induced decrease in forskolin-stimulated cAMP production by TR-FRET assay | ChEMBL. | 18258439 |
IC50 (functional) | = 0.15 uM | Activity at human adenosine A1 receptor expressed in CHO cells assessed as inhibition of CPA-induced decrease in forskolin-stimulated cAMP production by TR-FRET assay | ChEMBL. | 18258439 |
Kb (functional) | = 3 nM | Activity at human adenosine A1 receptor expressed in CHO cells assessed as inhibition of CPA-induced decrease in forskolin-stimulated cAMP production by TR-FRET assay | ChEMBL. | 18258439 |
Kb (functional) | = 3 nM | Activity at human adenosine A1 receptor expressed in CHO cells assessed as inhibition of CPA-induced decrease in forskolin-stimulated cAMP production by TR-FRET assay | ChEMBL. | 18258439 |
Ki (binding) | = 1.2 nM | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells | ChEMBL. | 18258439 |
Ki (binding) | = 1.2 nM | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells | ChEMBL. | 18258439 |
Ki (binding) | = 159 nM | Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells | ChEMBL. | 18258439 |
Ki (binding) | = 159 nM | Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells | ChEMBL. | 18258439 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.