Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 1 | 1 |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.0227 | 1 | 1 |
Echinococcus multilocularis | peptidyl glycine alpha amidating monooxygenase | 0.0227 | 1 | 0.5 |
Echinococcus granulosus | peptidyl glycine alpha amidating monooxygenase | 0.0227 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 31 uM | Antagonist activity at AMPA receptor in rat cerebral granule cells assessed as inhibition of kainate-induced calcium uptake after 30 mins | ChEMBL. | 18083036 |
IC50 (binding) | > 100 uM | Displacement of [3H]CP526427 from AMPA receptor in Sprague-Dawley rat fore brain by radioligand binding assay | ChEMBL. | 18083036 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.