Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Elongation factor 1-alpha | 0.0012 | 1 | 1 |
Echinococcus multilocularis | g1 to s phase transition protein | 0.0002 | 0.0301 | 0.0301 |
Leishmania major | elongation factor 1-alpha | 0.0012 | 1 | 1 |
Echinococcus multilocularis | elongation factor tu (ef tu) | 0.0002 | 0.0301 | 0.0301 |
Giardia lamblia | Elongation factor 1-alpha | 0.0012 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | elongation factor Tu | 0.0002 | 0.0301 | 0.5 |
Trichomonas vaginalis | elongation factor 1-alpha, putative | 0.0011 | 0.9691 | 0.9691 |
Mycobacterium leprae | PROBABLE IRON-REGULATED ELONGATION FACTOR TU TUF (EF-TU) | 0.0002 | 0.0301 | 0.5 |
Leishmania major | elongation factor 1-alpha | 0.0012 | 1 | 1 |
Leishmania major | elongation factor 1-alpha | 0.0012 | 1 | 1 |
Trypanosoma cruzi | elongation factor 1-alpha, putative | 0.0012 | 0.9991 | 0.9991 |
Loa Loa (eye worm) | elongation factor Tu1 | 0.0002 | 0.0301 | 0.0301 |
Schistosoma mansoni | hypothetical protein | 0.0002 | 0.0301 | 0.0301 |
Onchocerca volvulus | 0.0012 | 1 | 0.5 | |
Leishmania major | elongation factor 1-alpha | 0.0012 | 1 | 1 |
Echinococcus granulosus | elongation factor 1 alpha | 0.0012 | 1 | 1 |
Treponema pallidum | elongation factor Tu | 0.0002 | 0.0301 | 0.5 |
Plasmodium vivax | elongation factor Tu, mitochondrial precursor, putative | 0.0002 | 0.0301 | 0.0301 |
Schistosoma mansoni | elongation factor tu (ef-tu) | 0.0002 | 0.0301 | 0.0301 |
Trichomonas vaginalis | sulfate adenylyltransferase subunit, putative | 0.0002 | 0.0301 | 0.0301 |
Echinococcus multilocularis | elongation factor 1 alpha | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | elongation factor 1-alpha | 0.0012 | 1 | 1 |
Trypanosoma cruzi | elongation factor 1-alpha, putative | 0.0012 | 1 | 1 |
Plasmodium falciparum | elongation factor 1-alpha | 0.0012 | 1 | 1 |
Schistosoma mansoni | elongation factor tu (ef-tu) | 0.0002 | 0.0301 | 0.0301 |
Trypanosoma cruzi | elongation factor 1-alpha, putative | 0.0012 | 1 | 1 |
Onchocerca volvulus | 0.0012 | 1 | 0.5 | |
Leishmania major | elongation factor 1-alpha | 0.0012 | 1 | 1 |
Plasmodium falciparum | elongation factor Tu, putative | 0.0002 | 0.0301 | 0.0301 |
Trypanosoma brucei | EF-1-alpha | 0.0002 | 0.0301 | 0.0301 |
Echinococcus granulosus | g1 to s phase transition protein | 0.0002 | 0.0301 | 0.0301 |
Trypanosoma cruzi | elongation factor 1-alpha, putative | 0.0012 | 1 | 1 |
Leishmania major | elongation factor 1-alpha | 0.0012 | 1 | 1 |
Mycobacterium ulcerans | elongation factor Tu | 0.0002 | 0.0301 | 0.5 |
Schistosoma mansoni | elongation factor 1-alpha (ef-1-alpha) | 0.0012 | 1 | 1 |
Entamoeba histolytica | elongation factor 1-alpha 1 | 0.0012 | 1 | 1 |
Leishmania major | elongation factor 1-alpha | 0.0012 | 1 | 1 |
Trypanosoma brucei | elongation factor 1-alpha | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | elongation factor Tu domain-containing protein | 0.0002 | 0.0301 | 0.0301 |
Schistosoma mansoni | elongation factor 1-alpha (ef-1-alpha) | 0.0002 | 0.0292 | 0.0292 |
Trypanosoma cruzi | elongation factor 1-alpha, putative | 0.0012 | 1 | 1 |
Toxoplasma gondii | elongation factor tu, apicoplast, putative | 0.0002 | 0.0301 | 0.0301 |
Toxoplasma gondii | elongation factor 1-alpha (EF-1-ALPHA), putative | 0.0012 | 1 | 1 |
Entamoeba histolytica | elongation factor 1-alpha 1 | 0.0012 | 1 | 1 |
Echinococcus granulosus | elongation factor tu ef tu | 0.0002 | 0.0301 | 0.0301 |
Trypanosoma brucei | elongation factor 1-alpha | 0.0012 | 1 | 1 |
Trichomonas vaginalis | elongation factor 1-alpha, putative | 0.0012 | 1 | 1 |
Trypanosoma brucei | elongation factor 1-alpha | 0.0012 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | elongation factor Tu | 0.0002 | 0.0301 | 0.5 |
Toxoplasma gondii | elongation factor 1-alpha (EF-1-ALPHA), putative | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic translation elongation factor 1A | 0.0012 | 1 | 1 |
Brugia malayi | elongation factor Tu homologue precursor | 0.0002 | 0.0301 | 0.0301 |
Trichomonas vaginalis | translation factor, putative | 0.0012 | 0.9991 | 0.9991 |
Brugia malayi | Elongation factor Tu C-terminal domain containing protein | 0.0002 | 0.0301 | 0.0301 |
Trypanosoma cruzi | elongation factor 1-alpha, putative | 0.0012 | 1 | 1 |
Plasmodium vivax | elongation factor 1-alpha, putative | 0.0012 | 1 | 1 |
Toxoplasma gondii | elongation factor Tu, putative | 0.0002 | 0.0301 | 0.0301 |
Chlamydia trachomatis | elongation factor Tu | 0.0002 | 0.0301 | 0.5 |
Plasmodium falciparum | elongation factor 1-alpha | 0.0012 | 1 | 1 |
Leishmania major | elongation factor Tu, putative | 0.0002 | 0.0301 | 0.0301 |
Brugia malayi | elongation factor 1-alpha (EF-1-alpha) | 0.0012 | 1 | 1 |
Plasmodium falciparum | elongation factor Tu | 0.0002 | 0.0301 | 0.0301 |
Trichomonas vaginalis | translation factor, putative | 0.0012 | 1 | 1 |
Entamoeba histolytica | elongation factor 1-alpha 1 | 0.0012 | 1 | 1 |
Trypanosoma cruzi | elongation factor 1-alpha, putative | 0.0012 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 46.2 uM | Cytotoxicity against human C8166 cells after 72 hrs by MTT method | ChEMBL. | 18316190 |
CC50 (ADMET) | = 46.2 uM | Cytotoxicity against human C8166 cells after 72 hrs by MTT method | ChEMBL. | 18316190 |
EC50 (functional) | = 60.1 uM | Antiviral activity against HIV1 3B in C8166 cells by syncytium reduction assay | ChEMBL. | 18316190 |
Ratio CC50/EC50 (functional) | = 7.7 | Selectivity index, ratio of CC50 for C8166 cells to EC50 for HIV1 3B | ChEMBL. | 18316190 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.