Detailed view for TcCLB.511369.20

Basic information

TDR Targets ID: 30293
Trypanosoma cruzi, elongation factor 1-alpha, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 9.087 | Length (AA): 449 | MW (Da): 49157 | Paralog Number: 6

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00009   Elongation factor Tu GTP binding domain
PF03143   Elongation factor Tu C-terminal domain
PF03144   Elongation factor Tu domain 2

Gene Ontology

Mouse over links to read term descriptions.
GO:0005737   cytoplasm  
GO:0003924   GTPase activity  
GO:0003746   translation elongation factor activity  
GO:0005525   GTP binding  
GO:0006414   translational elongation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 431 1f60 (A) 2 441 77.00 0 1 1.92 -1.32
4 449 1wb1 (A) 2 423 22.00 0 1 0.87 1.17
4 443 4c0s (A) 4 455 79.00 0 1 1.93816 -1.11
228 313 1xe1 (A) 20 102 24.00 0 0.94 0.565937 -1.18

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile metacyclic. Smircich P
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile epimastigote. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_126631)

Species Accession Gene Product
Arabidopsis thaliana AT5G60390   elongation factor 1-alpha 4
Arabidopsis thaliana AT1G07920   elongation factor 1-alpha 3
Arabidopsis thaliana AT1G07940   elongation factor 1-alpha 1
Babesia bovis BBOV_IV010630   elongation factor 1-alpha
Babesia bovis BBOV_IV010620   elongation factor 1-alpha
Brugia malayi Bm1_27170   elongation factor 1-alpha (EF-1-alpha)
Brugia malayi Bm1_09680   elongation factor 1-alpha
Candida albicans CaO19.9009   One of 3 closely related C. albicans translation elongation factor EF-1 alpha genes
Candida albicans CaO19.12585   One of 3 closely related translation elongation factor EF-1 alpha genes
Candida albicans CaO19.8012   One of 3 closely related C. albicans translation elongation factor EF-1 alpha genes
Candida albicans CaO19.382   One of 3 closely related C. albicans translation elongation factor EF-1 alpha genes
Candida albicans CaO19.1435   One of 3 closely related C. albicans translation elongation factor EF-1 alpha genes
Candida albicans CaO19.5119   One of 3 closely related translation elongation factor EF-1 alpha genes
Caenorhabditis elegans CELE_R03G5.1   Protein EEF-1A.2, isoform C
Caenorhabditis elegans CELE_F31E3.5   Protein EEF-1A.1
Cryptosporidium hominis Chro.60459   elongation factor 1-alpha (EF-1-ALPHA)
Cryptosporidium parvum cgd6_3990   elongation factor 1 alpha
Dictyostelium discoideum DDB_G0269136   elongation factor 1 alpha
Dictyostelium discoideum DDB_G0269134   elongation factor 1 alpha
Drosophila melanogaster Dmel_CG1873   Elongation factor 1alpha100E
Drosophila melanogaster Dmel_CG8280   Elongation factor 1alpha48D
Echinococcus granulosus EgrG_000982200   elongation factor 1 alpha
Entamoeba histolytica EHI_102170   elongation factor 1-alpha 1
Entamoeba histolytica EHI_011210   elongation factor 1-alpha 1
Entamoeba histolytica EHI_052400   elongation factor 1-alpha 1
Echinococcus multilocularis EmuJ_000982200   elongation factor 1 alpha
Giardia lamblia GL50803_112304   Elongation factor 1-alpha
Giardia lamblia GL50803_112312   Elongation factor 1-alpha
Homo sapiens ENSG00000156508   eukaryotic translation elongation factor 1 alpha 1
Homo sapiens ENSG00000101210   eukaryotic translation elongation factor 1 alpha 2
Leishmania braziliensis LbrM.17.0090   elongation factor 1-alpha
Leishmania donovani LdBPK_170170.1   elongation factor 1-alpha
Leishmania infantum LinJ.17.0200   elongation factor 1-alpha
Leishmania infantum LinJ.17.0100   elongation factor 1-alpha
Leishmania infantum LinJ.17.0110   elongation factor 1-alpha
Leishmania infantum LinJ.17.0090   elongation factor 1-alpha
Leishmania infantum LinJ.17.0170   elongation factor 1-alpha
Leishmania infantum LinJ.17.0180   elongation factor 1-alpha
Leishmania infantum LinJ.17.0190   elongation factor 1-alpha
Leishmania major LmjF.17.0081   elongation factor 1-alpha
Leishmania major LmjF.17.0085   elongation factor 1-alpha
Leishmania major LmjF.17.0083   elongation factor 1-alpha
Leishmania major LmjF.17.0082   elongation factor 1-alpha
Leishmania major LmjF.17.0084   elongation factor 1-alpha
Leishmania major LmjF.17.0080   elongation factor 1-alpha
Leishmania major LmjF.17.0086   elongation factor 1-alpha
Leishmania mexicana LmxM.17.0082   elongation factor 1-alpha
Leishmania mexicana LmxM.17.0085   elongation factor 1-alpha
Leishmania mexicana LmxM.17.0081   elongation factor 1-alpha
Leishmania mexicana LmxM.17.0080   elongation factor 1-alpha
Loa Loa (eye worm) LOAG_06320   elongation factor 1-alpha
Loa Loa (eye worm) LOAG_08753   eukaryotic translation elongation factor 1A
Mus musculus ENSMUSG00000037742   eukaryotic translation elongation factor 1 alpha 1
Mus musculus ENSMUSG00000016349   eukaryotic translation elongation factor 1 alpha 2
Neospora caninum NCLIV_001670   Elongation factor 1-alpha, related
Neospora caninum NCLIV_014180   Elongation factor 1-alpha, related
Oryza sativa 4331810   Os03g0177400
Oryza sativa 4331811   Os03g0177500
Oryza sativa 4331813   Os03g0178000
Oryza sativa 4331812   Os03g0177900
Onchocerca volvulus OVOC11940  
Onchocerca volvulus OVOC1671  
Plasmodium berghei PBANKA_1133300   elongation factor 1-alpha
Plasmodium berghei PBANKA_1133400   elongation factor 1-alpha
Plasmodium falciparum PF3D7_1357000   elongation factor 1-alpha
Plasmodium falciparum PF3D7_1357100   elongation factor 1-alpha
Plasmodium knowlesi PKNH_1114400   elongation factor 1-alpha, putative
Plasmodium knowlesi PKNH_1114500   elongation factor 1-alpha
Plasmodium vivax PVX_114832   elongation factor 1-alpha, putative
Plasmodium yoelii PY00362   translation elongation factor EF-1, subunit alpha
Plasmodium yoelii PY00361   translation elongation factor EF-1, subunit alpha
Plasmodium yoelii PY02338   translation elongation factor EF-1, subunit alpha
Saccharomyces cerevisiae YPR080W   translation elongation factor EF-1 alpha
Saccharomyces cerevisiae YBR118W   translation elongation factor EF-1 alpha
Schistosoma japonicum Sjp_0054280   ko:K03231 elongation factor EF-1 alpha subunit, putative
Schistosoma mansoni Smp_099870   elongation factor 1-alpha (ef-1-alpha)
Schmidtea mediterranea mk4.000421.02  
Schmidtea mediterranea mk4.000076.22  
Schmidtea mediterranea mk4.000753.07  
Schmidtea mediterranea mk4.000969.05  
Schmidtea mediterranea mk4.020804.02  
Schmidtea mediterranea mk4.000498.08  
Schmidtea mediterranea mk4.000094.10  
Schmidtea mediterranea mk4.002287.01  
Trypanosoma brucei gambiense Tbg972.10.2530   elongation factor 1-alpha, putative
Trypanosoma brucei gambiense Tbg972.10.2550   elongation factor 1-alpha, putative
Trypanosoma brucei Tb927.10.2110   elongation factor 1-alpha
Trypanosoma brucei Tb927.10.2100   elongation factor 1-alpha
Trypanosoma brucei Tb927.10.2090   elongation factor 1-alpha
Trypanosoma congolense TcIL3000_10_1740   elongation factor 1-alpha, putative
Trypanosoma cruzi TcCLB.510119.9   elongation factor 1-alpha, putative
Trypanosoma cruzi TcCLB.511369.20   elongation factor 1-alpha, putative
Trypanosoma cruzi TcCLB.511369.30   elongation factor 1-alpha, putative
Trypanosoma cruzi TcCLB.511367.370   elongation factor 1-alpha, putative
Trypanosoma cruzi TcCLB.511369.10   elongation factor 1-alpha, putative
Trypanosoma cruzi TcCLB.510119.20   elongation factor 1-alpha, putative
Trypanosoma cruzi TcCLB.511367.360   elongation factor 1-alpha, putative
Toxoplasma gondii TGME49_294800   elongation factor 1-alpha (EF-1-ALPHA), putative
Toxoplasma gondii TGME49_286420   elongation factor 1-alpha (EF-1-ALPHA), putative
Theileria parva TP01_0726   elongation factor 1 alpha, putative
Trichomonas vaginalis TVAG_463940   translation factor, putative
Trichomonas vaginalis TVAG_354100   elongation factor 1-alpha, putative
Trichomonas vaginalis TVAG_013320   translation factor, putative
Trichomonas vaginalis TVAG_067400   elongation factor 1-alpha, putative

Essentiality

TcCLB.511369.20 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.2090 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.2090 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.2090 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.2090 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F31E3.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_F31E3.5 Caenorhabditis elegans larval arrest wormbase
CELE_F31E3.5 Caenorhabditis elegans larval lethal wormbase
CELE_F31E3.5 Caenorhabditis elegans slow growth wormbase
CELE_F31E3.5 Caenorhabditis elegans sterile wormbase
CELE_R03G5.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_R03G5.1 Caenorhabditis elegans larval arrest wormbase
CELE_R03G5.1 Caenorhabditis elegans slow growth wormbase
CELE_R03G5.1 Caenorhabditis elegans sterile wormbase
PBANKA_1133400 Plasmodium berghei Slow plasmo
TGME49_286420 Toxoplasma gondii Probably non-essential sidik
TGME49_294800 Toxoplasma gondii Probably non-essential sidik
TGME49_286420 Toxoplasma gondii Probably essential sidik
TGME49_294800 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Leishmania major elongation factor 1-alpha Compounds References
Homo sapiens eukaryotic translation elongation factor 1 alpha 2 Compounds References
Homo sapiens eukaryotic translation elongation factor 1 alpha 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0026 1 1
0.0045 1 1
0.0012 1 1
0.0045 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier TcCLB.511369.20 (Trypanosoma cruzi), elongation factor 1-alpha, putative
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