Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0101 | 1 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0101 | 1 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0101 | 1 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0101 | 1 | 0.5 |
Trypanosoma cruzi | hexose transporter | 0.0031 | 0 | 0.5 |
Plasmodium vivax | hexose transporter | 0.0101 | 1 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0101 | 1 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0101 | 1 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0101 | 1 | 1 |
Leishmania major | glucose transporter, lmgt1 | 0.0031 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0031 | 0 | 0.5 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | sugar transporter | 0.0101 | 1 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0101 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0031 | 0 | 0.5 |
Leishmania major | glucose transporter/membrane transporter D2, putative | 0.0031 | 0 | 0.5 |
Leishmania major | glucose transporter, lmgt2 | 0.0031 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter 2A | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.0101 | 1 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0031 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0031 | 0 | 0.5 |
Trypanosoma cruzi | hexose transporter, putative | 0.0031 | 0 | 0.5 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0031 | 0 | 0.5 |
Plasmodium falciparum | hexose transporter | 0.0101 | 1 | 0.5 |
Trypanosoma cruzi | hexose transporter, putative | 0.0031 | 0 | 0.5 |
Leishmania major | glucose transporter, lmgt3 | 0.0031 | 0 | 0.5 |
Trypanosoma cruzi | hexose transporter, putative | 0.0031 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0101 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0101 | 1 | 1 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0031 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0031 | 0 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0101 | 1 | 1 |
Trypanosoma brucei | glucose transporter 1E | 0.0031 | 0 | 0.5 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0101 | 1 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0101 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0031 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | > 727.3 uM | Cytotoxicity against human C8166 cells after 72 hrs by MTT method | ChEMBL. | 18316190 |
CC50 (ADMET) | > 727.3 uM | Cytotoxicity against human C8166 cells after 72 hrs by MTT method | ChEMBL. | 18316190 |
EC50 (functional) | = 51.8 uM | Antiviral activity against HIV1 3B in C8166 cells by syncytium reduction assay | ChEMBL. | 18316190 |
Ratio CC50/EC50 (functional) | > 14 | Selectivity index, ratio of CC50 for C8166 cells to EC50 for HIV1 3B | ChEMBL. | 18316190 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.