Detailed information for compound 517612

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 361.394 | Formula: C21H19N3O3
  • H donors: 3 H acceptors: 3 LogP: 1.02 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCC(Cn1cc(c2c1cccc2)C1=C(C(=O)NC1=O)c1ccccc1)O
  • InChi: 1S/C21H19N3O3/c22-10-14(25)11-24-12-16(15-8-4-5-9-17(15)24)19-18(20(26)23-21(19)27)13-6-2-1-3-7-13/h1-9,12,14,25H,10-11,22H2,(H,23,26,27)
  • InChiKey: SJJFYAKGAZYRHR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens calcium/calmodulin-dependent protein kinase II delta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis calcium-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calcium-dependent protein kinase-3 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis calmodulin-domain protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK3 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calmodulin-domain protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK2A Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK2B Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis CDPK2 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II delta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calcium-dept. protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii Plasmodium falciparum CDPK2 protein Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calmodulin-domain protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K08794 calcium/calmodulin-dependent protein kinase I, putative Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Cam kinase protein 1 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) CAMK/CAMK2 protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 2 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 5, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Calcium-dependent protein kinase 2, related Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II alpha chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Calmodulin-like domain protein kinase isoenzyme gamma, related Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva calmodulin-domain protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II beta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0143 0.3856 0.3847
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0466 0.0453
Schistosoma mansoni histone deacetylase hda2 0.0043 0.077 0.0758
Leishmania major histone deacetylase, putative 0.0186 0.5184 1
Brugia malayi Pre-SET motif family protein 0.0231 0.658 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.017 0.0302
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.017 0.0258
Schistosoma mansoni histone deacetylase 0.0043 0.077 0.0758
Brugia malayi histone deacetylase 11 0.0043 0.077 0.117
Brugia malayi histone deacetylase 3 (HD3) 0.0043 0.077 0.117
Schistosoma mansoni histone deacetylase 0.0043 0.077 0.0758
Schistosoma mansoni histone deacetylase 4 5 0.0186 0.5184 0.5177
Brugia malayi histone deacetylase 1 (HD1) 0.0043 0.077 0.117
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0306 0.0567
Leishmania major importin beta-1 subunit, putative 0.0026 0.0244 0.0446
Echinococcus multilocularis histone deacetylase 0.0186 0.5184 0.5183
Echinococcus multilocularis histone deacetylase 1 0.0043 0.077 0.0768
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0431 0.0807
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.077 0.1197
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0018 0.0013 0.0011
Trypanosoma brucei histone deacetylase 3 0.0186 0.5184 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0152 0.4135 0.4134
Trypanosoma cruzi histone deacetylase 1, putative 0.0043 0.077 0.1197
Echinococcus multilocularis histone deacetylase 7 0.0186 0.5184 0.5183
Leishmania major GTP-binding protein, putative 0.0024 0.017 0.0302
Echinococcus multilocularis snurportin 1 0.0342 1 1
Trypanosoma cruzi histone deacetylase, putative 0.0186 0.5184 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0306 0.0293
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0244 0.0148
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0306 0.0273
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0466 0.0453
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.017 0.0302
Schistosoma mansoni ran 0.0024 0.017 0.0157
Trichomonas vaginalis histone deacetylase, putative 0.0043 0.077 0.1002
Trichomonas vaginalis set domain proteins, putative 0.0263 0.7567 1
Plasmodium vivax histone deacetylase, putative 0.0186 0.5184 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.017 0.0157
Leishmania major histone deacetylase, putative 0.0043 0.077 0.1463
Plasmodium vivax histone deacetylase 2, putative 0.0186 0.5184 1
Brugia malayi RNA, U transporter 1 0.0091 0.2254 0.3426
Schistosoma mansoni protein kinase 0.0152 0.4135 0.4128
Plasmodium vivax SET domain protein, putative 0.0033 0.0466 0.0875
Entamoeba histolytica histone deacetylase, putative 0.0043 0.077 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0466 0.0464
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0231 0.658 0.6576
Brugia malayi Histone deacetylase family protein 0.0186 0.5184 0.7878
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0043 0.077 0.1002
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0018 0.0013 0.002
Leishmania major hypothetical protein, conserved 0.0028 0.0306 0.0567
Echinococcus granulosus histone deacetylase 7 0.0186 0.5184 0.5183
Echinococcus granulosus histone deacetylase 8 0.0043 0.077 0.0768
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.017 0.0302
Toxoplasma gondii histone deacetylase HDAC3 0.0043 0.077 0.1463
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0466 0.0453
Toxoplasma gondii histone deacetylase HDAC4 0.0043 0.077 0.1463
Echinococcus multilocularis histone deacetylase 8 0.0043 0.077 0.0768
Echinococcus granulosus importin subunit beta 1 0.0032 0.0431 0.0429
Plasmodium vivax importin-beta 2, putative 0.0032 0.0431 0.0807
Trypanosoma cruzi histone deacetylase 1, putative 0.0043 0.077 0.1197
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0428 0.0426
Trichomonas vaginalis histone deacetylase, putative 0.0043 0.077 0.1002
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0018 0.0013 0.0011
Trypanosoma cruzi histone deacetylase, putative 0.0186 0.5184 1
Loa Loa (eye worm) hypothetical protein 0.0143 0.3856 0.3847
Echinococcus multilocularis histone deacetylase 3 0.0043 0.077 0.0768
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0431 0.0429
Toxoplasma gondii histone deacetylase HDAC1 0.0186 0.5184 1
Brugia malayi Histone deacetylase family protein 0.0186 0.5184 0.7878
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0043 0.077 0.1002
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0306 0.0567
Schistosoma mansoni protein kinase 0.0152 0.4135 0.4128
Brugia malayi Histone deacetylase 1 0.0043 0.077 0.117
Toxoplasma gondii histone deacetylase HDAC5 0.0043 0.077 0.1463
Loa Loa (eye worm) histone deacetylase 1 0.0043 0.077 0.0758
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0244 0.0305
Trichomonas vaginalis histone deacetylase, putative 0.0043 0.077 0.1002
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0306 0.0273
Trypanosoma brucei histone deacetylase 4 0.0186 0.5184 1
Trypanosoma brucei histone deacetylase, putative 0.0186 0.5184 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.017 0.0168
Loa Loa (eye worm) hypothetical protein 0.0043 0.077 0.0758
Schistosoma mansoni hypothetical protein 0.0342 1 1
Echinococcus granulosus histone deacetylase 6 0.0186 0.5184 0.5183
Brugia malayi Importin beta-1 subunit 0.0032 0.0431 0.0655
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0152 0.4135 0.4134
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0466 0.0464
Brugia malayi Pre-SET motif family protein 0.0033 0.0466 0.0708
Plasmodium vivax histone deacetylase, putative 0.0043 0.077 0.1463
Onchocerca volvulus 0.0263 0.7567 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0466 0.0464
Loa Loa (eye worm) histone deacetylase 3 0.0043 0.077 0.0758
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0306 0.0567
Toxoplasma gondii histone deacetylase HDAC2 0.0043 0.077 0.1463
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.017 0.0168
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0431 0.0807
Giardia lamblia Histone deacetylase 0.0043 0.077 1
Plasmodium falciparum histone deacetylase 2 0.0186 0.5184 1
Trypanosoma brucei histone deacetylase 2 0.0043 0.077 0.1463
Entamoeba histolytica Ran family GTPase 0.0024 0.017 0.2067
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0306 0.0567
Loa Loa (eye worm) histone deacetylase 0.0186 0.5184 0.5177
Brugia malayi Cam kinase protein 1 0.0018 0.0013 0.002
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0043 0.077 0.1002
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0018 0.0013 0.0011
Entamoeba histolytica hypothetical protein 0.0026 0.0244 0.3046
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0244 0.0305
Leishmania major histone deacetylase, putative 0.0186 0.5184 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0466 0.0453
Echinococcus granulosus histone deacetylase 1 0.0043 0.077 0.0768
Schistosoma mansoni ran 0.0024 0.017 0.0157
Plasmodium falciparum histone deacetylase 1 0.0043 0.077 0.1463
Echinococcus granulosus histone deacetylase 3 0.0043 0.077 0.0768
Echinococcus multilocularis histone deacetylase 6 0.0186 0.5184 0.5183
Loa Loa (eye worm) histone deacetylase 7A 0.0186 0.5184 0.5177
Schistosoma mansoni histone deacetylase 4 5 0.0186 0.5184 0.5177
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0466 0.0875
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0018 0.0013 0.0011
Plasmodium vivax histone deacetylase 1, putative 0.0043 0.077 0.1463
Onchocerca volvulus Histone deacetylase 10 homolog 0.0043 0.077 0.0428
Loa Loa (eye worm) hypothetical protein 0.0043 0.077 0.0758
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0431 0.0807
Brugia malayi hypothetical protein 0.0028 0.0306 0.0466
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0133 0.3564 0.3555
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.077 0.1197
Trypanosoma brucei histone deacetylase 1 0.0043 0.077 0.1463
Schistosoma mansoni protein kinase 0.0152 0.4135 0.4128
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0306 0.0567
Plasmodium falciparum importin beta, putative 0.0032 0.0431 0.0807
Leishmania major histone deacetylase, putative 0.0043 0.077 0.1463
Trichomonas vaginalis ran, putative 0.0024 0.017 0.0207
Echinococcus granulosus histone deacetylase 6 0.0186 0.5184 0.5183
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0244 0.0305
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0018 0.0013 0.0011
Schistosoma mansoni histone deacetylase 1 2 3 0.0043 0.077 0.0758
Trichomonas vaginalis histone deacetylase, putative 0.0043 0.077 0.1002
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0133 0.3564 0.5416
Schistosoma mansoni histone deacetylase hda2 0.0186 0.5184 0.5177
Loa Loa (eye worm) hypothetical protein 0.0033 0.0466 0.0453
Echinococcus granulosus histone deacetylase 0.0186 0.5184 0.5183
Echinococcus multilocularis histone deacetylase 6 0.0186 0.5184 0.5183
Trypanosoma cruzi histone deacetylase, putative 0.0186 0.5184 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0342 1 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0018 0.0013 0.0011
Echinococcus granulosus histone deacetylase 6 0.0186 0.5184 0.5183
Trichomonas vaginalis histone deacetylase, putative 0.0043 0.077 0.1002
Loa Loa (eye worm) histone deacetylase 11 0.0043 0.077 0.0758
Loa Loa (eye worm) hypothetical protein 0.0032 0.0431 0.0418
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.017 0.0302
Schistosoma mansoni importin beta-1 0.0032 0.0431 0.0418
Plasmodium falciparum histone deacetylase, putative 0.0186 0.5184 1
Trichomonas vaginalis histone deacetylase, putative 0.0043 0.077 0.1002
Echinococcus multilocularis histone deacetylase 6 0.0186 0.5184 0.5183

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.45 uM Inhibition of CaMK2delta (unknown origin) ChEMBL. 18334295
IC50 (binding) = 0.45 uM Inhibition of CaMK2delta (unknown origin) ChEMBL. 18334295

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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