Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | colony stimulating factor 1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | Get druggable targets OG5_132967 | All targets in OG5_132967 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Putative organic anion transporter | 0.0083 | 0.052 | 0.0219 |
Onchocerca volvulus | Putative organic anion transporter | 0.1254 | 1 | 1 |
Onchocerca volvulus | 0.0083 | 0.052 | 0.0219 | |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.052 | 0.052 |
Onchocerca volvulus | Putative organic anion transporter | 0.0083 | 0.052 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0307 | 0.0307 |
Schistosoma mansoni | organic anion transporter | 0.0083 | 0.052 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.002 | 0.001 | 0.001 |
Echinococcus multilocularis | Solute carrier organic anion transporter family | 0.0083 | 0.052 | 1 |
Onchocerca volvulus | 0.0083 | 0.052 | 0.0219 | |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.052 | 0.052 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.052 | 0.052 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0307 | 0.0307 |
Brugia malayi | hypothetical protein | 0.0083 | 0.052 | 0.051 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.0057 | 0.0307 | 0.0297 |
Brugia malayi | SPARC precursor | 0.0057 | 0.0307 | 0.0297 |
Loa Loa (eye worm) | sodium-independent organic anion transporter | 0.0083 | 0.052 | 0.052 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.052 | 0.052 |
Schistosoma mansoni | follistatin | 0.0057 | 0.0307 | 0.5907 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.0057 | 0.0307 | 0.0297 |
Echinococcus multilocularis | follistatin | 0.0057 | 0.0307 | 0.5907 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.0501 | 0.3906 | 1 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0083 | 0.052 | 0.051 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.0057 | 0.0307 | 0.0297 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0083 | 0.052 | 0.051 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0083 | 0.052 | 0.051 |
Toxoplasma gondii | transporter, major facilitator family protein | 0.0083 | 0.052 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0307 | 0.0307 |
Loa Loa (eye worm) | agrin synaptic family protein | 0.0057 | 0.0307 | 0.0307 |
Schistosoma mansoni | agrin | 0.0057 | 0.0307 | 0.5907 |
Loa Loa (eye worm) | hypothetical protein | 0.1254 | 1 | 1 |
Echinococcus granulosus | agrin | 0.0057 | 0.0307 | 0.0786 |
Schistosoma mansoni | organic anion transporter | 0.0083 | 0.052 | 1 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.0057 | 0.0307 | 0.0297 |
Echinococcus granulosus | Solute carrier organic anion transporter family | 0.0083 | 0.052 | 0.133 |
Echinococcus multilocularis | agrin | 0.0057 | 0.0307 | 0.5907 |
Onchocerca volvulus | 0.0083 | 0.052 | 0.0219 | |
Echinococcus granulosus | organic anion transporting polypeptide 30B | 0.0083 | 0.052 | 0.133 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.052 | 0.052 |
Loa Loa (eye worm) | kazal-type serine protease inhibitor domain-containing protein | 0.0057 | 0.0307 | 0.0307 |
Onchocerca volvulus | 0.0083 | 0.052 | 0.0219 | |
Brugia malayi | hypothetical protein | 0.0083 | 0.052 | 0.051 |
Onchocerca volvulus | 0.0083 | 0.052 | 0.0219 | |
Echinococcus multilocularis | expressed protein | 0.0057 | 0.0307 | 0.5907 |
Trypanosoma cruzi | MFS transporter, putative | 0.0083 | 0.052 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.052 | 0.052 |
Echinococcus granulosus | follistatin | 0.0057 | 0.0307 | 0.0786 |
Brugia malayi | secreted modular calcium-binding protein 1 | 0.0057 | 0.0307 | 0.0297 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0307 | 0.0307 |
Echinococcus multilocularis | organic anion transporting polypeptide 30B | 0.0083 | 0.052 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.83 uM | Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization | ChEMBL. | 18289848 |
IC50 (binding) | = 0.83 uM | Inhibition of human cytoplasmic macrophage colony-stimulating factor 1 receptor by fluorescence polarization | ChEMBL. | 18289848 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.