Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.2408 | 0.3899 |
Loa Loa (eye worm) | matrixin family protein | 0.0152 | 0.5548 | 0.8983 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0118 | 0.4013 | 0.3846 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0097 | 0.3024 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0118 | 0.4013 | 0.6286 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0045 | 0.0655 | 0.1061 |
Echinococcus multilocularis | geminin | 0.017 | 0.6383 | 0.6283 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1724 | 0.2791 |
Onchocerca volvulus | Matrilysin homolog | 0.0152 | 0.5548 | 1 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.6383 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0097 | 0.3024 | 0.4896 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0068 | 0.1724 | 0.2791 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0085 | 0.2494 | 0.3907 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.6383 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.3024 | 0.4896 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0097 | 0.3024 | 0.283 |
Echinococcus granulosus | geminin | 0.017 | 0.6383 | 0.6283 |
Toxoplasma gondii | prolyl endopeptidase | 0.0097 | 0.3024 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.0083 | 0.2408 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.3036 | 0.4756 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0045 | 0.0655 | 0.1061 |
Trypanosoma brucei | prolyl endopeptidase | 0.0097 | 0.3024 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0152 | 0.5548 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0111 | 0.3674 | 0.5101 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0085 | 0.2494 | 0.2286 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.3674 | 0.595 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0083 | 0.2408 | 0.9321 |
Onchocerca volvulus | 0.0097 | 0.3036 | 0.3431 | |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0068 | 0.1724 | 0.2701 |
Schistosoma mansoni | lipoxygenase | 0.0083 | 0.2379 | 0.3727 |
Echinococcus granulosus | prolyl endopeptidase | 0.0097 | 0.3024 | 0.283 |
Brugia malayi | Matrixin family protein | 0.0165 | 0.6176 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0118 | 0.4013 | 0.3846 |
Brugia malayi | Matrixin family protein | 0.0068 | 0.1724 | 0.2791 |
Brugia malayi | Matrixin family protein | 0.0068 | 0.1724 | 0.2791 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.014 | 0.4995 | 0.4856 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1724 | 0.2791 |
Brugia malayi | jmjC domain containing protein | 0.0085 | 0.2494 | 0.4038 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0055 | 0.1085 | 0.1757 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0045 | 0.0655 | 0.1061 |
Loa Loa (eye worm) | matrixin family protein | 0.0165 | 0.6176 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0087 | 0.2558 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0249 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1724 | 0.2791 |
Brugia malayi | hypothetical protein | 0.0111 | 0.3674 | 0.595 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.3674 | 0.595 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0085 | 0.2494 | 0.2286 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0097 | 0.3024 | 0.4737 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0085 | 0.2494 | 0.4038 |
Brugia malayi | Matrixin family protein | 0.0068 | 0.1724 | 0.2791 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0655 | 0.1061 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0083 | 0.2408 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0111 | 0.3674 | 0.5101 |
Brugia malayi | jmjC domain containing protein | 0.014 | 0.4995 | 0.8088 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.01 | 0.3173 | 0.4971 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0083 | 0.2408 | 0.3899 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0085 | 0.2494 | 0.3907 |
Brugia malayi | Matrixin family protein | 0.0068 | 0.1724 | 0.2791 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0097 | 0.3024 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.014 | 0.4995 | 0.4856 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1312 | 0.2125 |
Brugia malayi | Hemopexin family protein | 0.0097 | 0.3036 | 0.4916 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0097 | 0.3024 | 0.3399 |
Schistosoma mansoni | jumonji domain containing protein | 0.0122 | 0.418 | 0.6548 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0097 | 0.3024 | 0.4737 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 243 nM | Inhibition of catalytic domain MMP9 (unknown origin) | ChEMBL. | 18086526 |
IC50 (binding) | = 243 nM | Inhibition of catalytic domain MMP9 (unknown origin) | ChEMBL. | 18086526 |
IC50 (binding) | = 1057 nM | Inhibition of full length MMP2 (unknown origin) | ChEMBL. | 18086526 |
IC50 (binding) | = 1057 nM | Inhibition of full length MMP2 (unknown origin) | ChEMBL. | 18086526 |
IC50 (binding) | > 10 uM | Inhibition of catalytic domain MMP1 (unknown origin) | ChEMBL. | 18086526 |
IC50 (binding) | > 10 uM | Inhibition of catalytic domain MMP1 (unknown origin) | ChEMBL. | 18086526 |
Ratio IC50 (binding) | = 4.3 | Selectivity ratio, IC50 for full length MMP2 (unknown origin) to IC50 for catalytic domain MMP9 (unknown origin) | ChEMBL. | 18086526 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.