Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | erb-b2 receptor tyrosine kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | sugar transporter | 0.011 | 0.4373 | 0.429 |
Echinococcus granulosus | epidermal growth factor receptor | 0.018 | 1 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.018 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.011 | 0.4373 | 0.4373 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.011 | 0.4373 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.011 | 0.4373 | 0.429 |
Trichomonas vaginalis | conserved hypothetical protein | 0.011 | 0.4373 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.3217 | 0.3117 |
Plasmodium vivax | hexose transporter | 0.011 | 0.4373 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.011 | 0.4373 | 0.429 |
Schistosoma mansoni | glucose transport protein | 0.011 | 0.4373 | 0.429 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0097 | 0.3299 | 0.3299 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.4373 | 0.429 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 1 | 1 |
Echinococcus granulosus | General substrate transporter | 0.0095 | 0.3128 | 0.3027 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.3299 | 0.32 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.011 | 0.4373 | 0.4373 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.011 | 0.4373 | 0.4373 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.3299 | 0.32 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.018 | 1 | 1 |
Schistosoma mansoni | glucose transport protein | 0.011 | 0.4373 | 0.429 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.3217 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.3217 | 0.3117 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.011 | 0.4373 | 0.429 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.011 | 0.4373 | 0.4373 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.011 | 0.4373 | 0.429 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0097 | 0.3299 | 0.32 |
Echinococcus multilocularis | General substrate transporter | 0.0095 | 0.3128 | 0.3128 |
Schistosoma mansoni | glucose transport protein | 0.011 | 0.4373 | 0.429 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0097 | 0.3299 | 0.32 |
Brugia malayi | Sugar transporter family protein | 0.011 | 0.4373 | 0.429 |
Plasmodium falciparum | hexose transporter | 0.011 | 0.4373 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0058 | 0.0145 | 0.0145 |
Echinococcus multilocularis | insulin receptor | 0.0058 | 0.0145 | 0.0145 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.035 uM | Inhibition of ebrB2 (unknown origin) expressed in human MCF7 cells by autophosphorylation assay | ChEMBL. | 18061446 |
IC50 (binding) | = 0.035 uM | Inhibition of ebrB2 (unknown origin) expressed in human MCF7 cells by autophosphorylation assay | ChEMBL. | 18061446 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.