Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | hexose transporter | 0.0205 | 1 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0205 | 1 | 1 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0063 | 0.1693 | 0.5 |
Trypanosoma cruzi | hexose transporter, putative | 0.0063 | 0.1693 | 1 |
Leishmania major | glucose transporter/membrane transporter D2, putative | 0.0063 | 0.1693 | 0.5 |
Trypanosoma cruzi | hexose transporter, putative | 0.0063 | 0.1693 | 1 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0205 | 1 | 1 |
Trypanosoma cruzi | hexose transporter, putative | 0.0063 | 0.1693 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0205 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0205 | 1 | 1 |
Trypanosoma cruzi | hexose transporter | 0.0063 | 0.1693 | 1 |
Trypanosoma brucei | glucose transporter 2A | 0.0063 | 0.1693 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0205 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0063 | 0.1693 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0063 | 0.1693 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0063 | 0.1693 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0063 | 0.1693 | 0.5 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0063 | 0.1693 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.0205 | 1 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.0205 | 1 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | sugar transporter | 0.0205 | 1 | 0.5 |
Leishmania major | glucose transporter, lmgt1 | 0.0063 | 0.1693 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0205 | 1 | 1 |
Trypanosoma brucei | glucose transporter 1E | 0.0063 | 0.1693 | 0.5 |
Plasmodium vivax | hexose transporter | 0.0205 | 1 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0205 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0063 | 0.1693 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0063 | 0.1693 | 0.5 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0205 | 1 | 0.5 |
Leishmania major | glucose transporter, lmgt3 | 0.0063 | 0.1693 | 0.5 |
Leishmania major | glucose transporter, lmgt2 | 0.0063 | 0.1693 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0063 | 0.1693 | 0.5 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0063 | 0.1693 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0205 | 1 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0205 | 1 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0063 | 0.1693 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 152.21 uM | Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay | ChEMBL. | 18035542 |
IC50 (functional) | = 152.21 uM | Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay | ChEMBL. | 18035542 |
IC50 (functional) | = 160.82 uM | Antiproliferative activity against human SW620 cells after 72 hrs by MTT assay | ChEMBL. | 18035542 |
IC50 (functional) | = 160.82 uM | Antiproliferative activity against human SW620 cells after 72 hrs by MTT assay | ChEMBL. | 18035542 |
IC50 (functional) | > 200 uM | Antiproliferative activity against human C33 cells after 72 hrs by MTT assay | ChEMBL. | 18035542 |
IC50 (functional) | > 200 uM | Antiproliferative activity against human SW480 cells after 72 hrs by MTT assay | ChEMBL. | 18035542 |
IC50 (functional) | > 200 uM | Antiproliferative activity against human K562 cells after 72 hrs by MTT assay | ChEMBL. | 18035542 |
IC50 (functional) | > 200 uM | Antiproliferative activity against human SW480 cells after 72 hrs by MTT assay | ChEMBL. | 18035542 |
IC50 (functional) | > 200 uM | Antiproliferative activity against human K562 cells after 72 hrs by MTT assay | ChEMBL. | 18035542 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.