Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Histamine H3 receptor | Starlite/ChEMBL | References |
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | biogenic amine 5HT receptor | Histamine H3 receptor | 445 aa | 405 aa | 25.2 % |
Loa Loa (eye worm) | hypothetical protein | Histamine H3 receptor | 445 aa | 384 aa | 22.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | glucose transporter, putative | 0.0033 | 0.1693 | 0.5 |
Leishmania major | glucose transporter, lmgt2 | 0.0033 | 0.1693 | 0.5 |
Leishmania major | glucose transporter, lmgt3 | 0.0033 | 0.1693 | 0.5 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0105 | 1 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0033 | 0.1693 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 1 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.0105 | 1 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0033 | 0.1693 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0105 | 1 | 1 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0033 | 0.1693 | 0.5 |
Trypanosoma brucei | glucose transporter 1E | 0.0033 | 0.1693 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0105 | 1 | 1 |
Leishmania major | glucose transporter, lmgt1 | 0.0033 | 0.1693 | 0.5 |
Loa Loa (eye worm) | sugar transporter | 0.0105 | 1 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0105 | 1 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0105 | 1 | 0.5 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0033 | 0.1693 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.0105 | 1 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0033 | 0.1693 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0033 | 0.1693 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0033 | 0.1693 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0105 | 1 | 1 |
Plasmodium vivax | hexose transporter | 0.0105 | 1 | 0.5 |
Trypanosoma brucei | glucose transporter 2A | 0.0033 | 0.1693 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0105 | 1 | 1 |
Trypanosoma cruzi | hexose transporter | 0.0033 | 0.1693 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0105 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0033 | 0.1693 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0033 | 0.1693 | 0.5 |
Leishmania major | glucose transporter/membrane transporter D2, putative | 0.0033 | 0.1693 | 0.5 |
Trypanosoma cruzi | hexose transporter, putative | 0.0033 | 0.1693 | 1 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0033 | 0.1693 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0105 | 1 | 1 |
Plasmodium falciparum | hexose transporter | 0.0105 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0105 | 1 | 1 |
Trypanosoma cruzi | hexose transporter, putative | 0.0033 | 0.1693 | 1 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0105 | 1 | 1 |
Trypanosoma cruzi | hexose transporter, putative | 0.0033 | 0.1693 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 34 nM | Binding affinity at human recombinant histamine H3 receptor expressed in HEK cells | ChEMBL. | 18077160 |
Ki (binding) | = 34 nM | Binding affinity at human recombinant histamine H3 receptor expressed in HEK cells | ChEMBL. | 18077160 |
Ki (binding) | = 140 nM | Binding affinity at rat recombinant histamine H3 receptor in rat cortical membranes | ChEMBL. | 18077160 |
Ki (binding) | = 140 nM | Binding affinity at rat recombinant histamine H3 receptor in rat cortical membranes | ChEMBL. | 18077160 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.