Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | long-chain-acyl-CoA synthetase | 0.0222 | 1 | 1 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.001 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0212 | 0.954 | 1 |
Echinococcus granulosus | long chain fatty acid transport protein 4 | 0.0215 | 0.9672 | 1 |
Schistosoma mansoni | FFA transport protein | 0.0215 | 0.9672 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.001 | 0 | 0.5 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.001 | 0 | 0.5 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Leishmania major | fatty acid transporter protein-like protein | 0.0212 | 0.954 | 1 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Mycobacterium leprae | possible long-chain acyl-CoA synthase | 0.0212 | 0.954 | 1 |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.001 | 0 | 0.5 |
Plasmodium falciparum | acetyl-CoA synthetase, putative | 0.001 | 0 | 0.5 |
Toxoplasma gondii | propionate-CoA ligase | 0.001 | 0 | 0.5 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.001 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid transporter protein-like, putative | 0.0215 | 0.9672 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | long chain fatty acid transport protein 4 | 0.0215 | 0.9672 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.001 | 0 | 0.5 |
Plasmodium vivax | acetyl-CoA synthetase, putative | 0.001 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid transporter protein-like, putative | 0.0215 | 0.9672 | 1 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.001 | 0 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.001 | 0 | 0.5 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0222 | 1 | 1 |
Onchocerca volvulus | 0.001 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 28 uM | Inhibition of CK2 in rat liver | ChEMBL. | 18251491 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.