Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | conserved hypothetical protein | 0.0041 | 0.0891 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0041 | 0.0891 | 0.5 |
Brugia malayi | Sugar transporter family protein | 0.0114 | 0.3917 | 0.5599 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 0.7156 | 1 |
Onchocerca volvulus | 0.0171 | 0.6295 | 1 | |
Mycobacterium ulcerans | beta-lactamase | 0.0041 | 0.0891 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0114 | 0.3917 | 0.483 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0114 | 0.3917 | 0.483 |
Schistosoma mansoni | glucose transport protein | 0.0114 | 0.3917 | 0.483 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0891 | 0.07 |
Brugia malayi | hypothetical protein | 0.0171 | 0.6295 | 1 |
Echinococcus multilocularis | General substrate transporter | 0.0098 | 0.3254 | 0.3771 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0114 | 0.3917 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0041 | 0.0891 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0891 | 0.07 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.0891 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0041 | 0.0891 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0891 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.6295 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0.0891 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0041 | 0.0891 | 0.5 |
Plasmodium vivax | hexose transporter | 0.0114 | 0.3917 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 0.7156 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0114 | 0.3917 | 0.483 |
Echinococcus granulosus | geminin | 0.0192 | 0.7156 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0114 | 0.3917 | 0.483 |
Schistosoma mansoni | hypothetical protein | 0.0114 | 0.3917 | 0.483 |
Schistosoma mansoni | glucose transport protein | 0.0114 | 0.3917 | 0.483 |
Trypanosoma cruzi | hexose transporter, putative | 0.0035 | 0.0663 | 0.7444 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0.0891 | 1 |
Trypanosoma cruzi | hexose transporter, putative | 0.0035 | 0.0663 | 0.7444 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0114 | 0.3917 | 0.483 |
Trypanosoma cruzi | hexose transporter | 0.0035 | 0.0663 | 0.7444 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0891 | 0.07 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0114 | 0.3917 | 0.483 |
Plasmodium falciparum | hexose transporter | 0.0114 | 0.3917 | 0.5 |
Trypanosoma cruzi | hexose transporter, putative | 0.0035 | 0.0663 | 0.7444 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0891 | 1 |
Loa Loa (eye worm) | sugar transporter | 0.0114 | 0.3917 | 0.5599 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0114 | 0.3917 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0891 | 0.07 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0114 | 0.3917 | 0.483 |
Trichomonas vaginalis | esterase, putative | 0.0041 | 0.0891 | 0.07 |
Echinococcus multilocularis | geminin | 0.0192 | 0.7156 | 1 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0114 | 0.3917 | 0.483 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0891 | 0.07 |
Echinococcus granulosus | General substrate transporter | 0.0098 | 0.3254 | 0.3771 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0114 | 0.3917 | 0.483 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of beta-mannosidase (unknown origin) | ChEMBL. | 18060793 | |
Activity (binding) | 0 | Inhibition of beta-mannosidase (unknown origin) | ChEMBL. | 18060793 |
IC50 (binding) | 0 | Inhibition of beta galactosidase (unknown origin) | ChEMBL. | 18060793 |
IC50 (binding) | = 2 mM | Inhibition of alpha mannosidase (unknown origin) | ChEMBL. | 18060793 |
IC50 (binding) | = 3 mM | Inhibition of alpha-L-fucosidase (unknown origin) | ChEMBL. | 18060793 |
IC50 (binding) | = 77 uM | Inhibition of alpha glucosidase (unknown origin) | ChEMBL. | 18060793 |
IC50 (binding) | = 234 uM | Inhibition of alpha galactosidase (unknown origin) | ChEMBL. | 18060793 |
IC50 (binding) | = 540 uM | Inhibition of beta glucosidase (unknown origin) | ChEMBL. | 18060793 |
Inhibition (functional) | = 44 % | Inhibition of IL4-secretion in BALB/c mouse splenocytes at 60 uM after 72 hrs by ELISA | ChEMBL. | 18060793 |
Inhibition (functional) | = 55.5 % | Inhibition of IFN-gamma secretion in BALB/c mouse splenocytes at 60 uM after 72 hrs by ELISA | ChEMBL. | 18060793 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.