Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.000433847 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.000406623 | 0.903603 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.000433847 | 1 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.000433847 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.000406623 | 0.903603 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.000406623 | 0.903603 | 0.903603 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.000433847 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.000406623 | 0.903603 | 0.903603 |
Plasmodium vivax | hypothetical protein, conserved | 0.000433847 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.000406623 | 0.903603 | 1 |
Chlamydia trachomatis | SWIB complex protein | 0.000433847 | 1 | 0.5 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.000433847 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.000406623 | 0.903603 | 0.903603 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.000433847 | 1 | 1 |
Loa Loa (eye worm) | brahma associated protein | 0.000433847 | 1 | 1 |
Schistosoma mansoni | brg-1 associated factor | 0.000433847 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.000433847 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.000433847 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.000406623 | 0.903603 | 1 |
Schistosoma mansoni | hypothetical protein | 0.000433847 | 1 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.000433847 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.000433847 | 1 | 0.5 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.000433847 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.000433847 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.000406623 | 0.903603 | 0.903603 |
Brugia malayi | Cytochrome P450 family protein | 0.000406623 | 0.903603 | 0.903603 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.000433847 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.000433847 | 1 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.000433847 | 1 | 0.5 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.000433847 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.000406623 | 0.903603 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.000266707 | 0.408177 | 0.408177 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.000433847 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.000433847 | 1 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.000433847 | 1 | 1 |
Onchocerca volvulus | 0.000433847 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.3 uM | Antiplasmodial activity against Plasmodium falciparum K1 by [3H]hypoxanthine incorporation assay | ChEMBL. | 18247550 |
IC50 (functional) | = 1.3 uM | Antiplasmodial activity against Plasmodium falciparum K1 by [3H]hypoxanthine incorporation assay | ChEMBL. | 18247550 |
IC50 (functional) | = 5.9 uM | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 | ChEMBL. | 18247550 |
IC50 (functional) | = 5.9 uM | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 | ChEMBL. | 18247550 |
IC50 (ADMET) | = 239.7 uM | Cytotoxicity against rat L6 cells | ChEMBL. | 18247550 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense | 18247550 | ||
Plasmodium falciparum | ChEMBL23 | 18247550 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.